Randomized single-blind comparative study of the midazolam/pethidine combination and midazolam alone during bronchoscopy

Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of the combination of midazolam and pethidine during bronchoscopy. In this prospective randomi...

Full description

Saved in:
Bibliographic Details
Published in:BMC cancer 2022-05, Vol.22 (1), p.539-539, Article 539
Main Authors: Katsurada, Masahiro, Tachihara, Motoko, Katsurada, Naoko, Takata, Naoya, Sato, Hiroki, Mimura, Chihiro, Yoshioka, Junya, Furukawa, Koichi, Yumura, Masako, Otoshi, Takehiro, Yasuda, Yuichiro, Kiriu, Tatsunori, Hazama, Daisuke, Nagano, Tatsuya, Yamamoto, Masatsugu, Nishimura, Yoshihiro, Kobayashi, Kazuyuki
Format: Article
Language:English
Subjects:
Adverse events
Analgesics
Anesthesia
Biopsy
Blood pressure
Bronchoscopy
Bronchoscopy - adverse effects
Bronchoscopy - methods
Conscious Sedation - methods
Dosage and administration
Fentanyl
Humans
Hypotension
Lung cancer
Meperidine
Methods
Midazolam
Midazolam - adverse effects
Morphine
Narcotics
Pain
Pain - etiology
Patients
Pethidine
Prospective Studies
Questionnaires
Sedation
Sedatives
Single-Blind Method
Statistical analysis
Testing
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of the combination of midazolam and pethidine during bronchoscopy. In this prospective randomized single (patient)-blind study, we randomly assigned 100 patients who were scheduled to undergo bronchoscopy biopsy to receive treatment with either the midazolam/pethidine combination (combination group) or midazolam alone (midazolam group) during examinations. After the end of bronchoscopy, patients completed a questionnaire and the visual analogue scale was measured. The primary outcome was the patients' acceptance of re-examination assessed by visual analogue scale. We also assessed pain levels, vital signs, midazolam use, xylocaine use, and adverse events. Univariate analyses were performed using Fisher's exact test for categorical data, and the t-test or Mann-Whitney test was carried out for analysis of numeric data. All P-values were two-sided, and values
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-022-09640-y