MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis

Background The aim was to use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (CC). Methods We evaluated blood flow in...

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Bibliographic Details
Published in:European radiology experimental 2018-09, Vol.2 (1), p.1-11, Article 26
Main Authors: Cox, Eleanor F., Palaniyappan, Naaventhan, Aithal, Guruprasad P., Guha, Indra N., Francis, Susan T.
Format: Article
Language:English
Subjects:
Arterial spin labelling (ASL)
Diagnostic Radiology
Imaging
Internal Medicine
Interventional Radiology
Liver cirrhosis
Magnetic resonance imaging (MRI)
Medicine
Medicine & Public Health
Neuroradiology
Original
Original Article
Perfusion
Radiology
T2 mapping
Ultrasound
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Summary:Background The aim was to use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (CC). Methods We evaluated blood flow in the portal vein, hepatic artery and azygos vein (using phase-contrast MRI), liver perfusion (using arterial spin labelling) and blood oxygenation (using transverse relaxation time [T2*] mapping). Measures were collected at baseline and at 6–7-min intervals from 20 to 65 min following a test meal (440 mL, 660 kcal) in 10 healthy participants and 10 patients with CC. Results In healthy participants, we observed a significant postprandial increase in portal vein flow from baseline (+ 137 ± 26% (mean ± standard deviation), p  
ISSN:2509-9280
2509-9280
DOI:10.1186/s41747-018-0056-3