Regional grafting of autologous adipose tissue is effective in inducing prompt healing of indolent digital ulcers in patients with systemic sclerosis: results of a monocentric randomized controlled study

A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healing in patients with systemic sclerosis (SSc). SSc patients with IDUs were randomized to be b...

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Bibliographic Details
Published in:Arthritis research & therapy 2019-01, Vol.21 (1), p.7-7, Article 7
Main Authors: Del Papa, Nicoletta, Di Luca, Gabriele, Andracco, Romina, Zaccara, Eleonora, Maglione, Wanda, Pignataro, Francesca, Minniti, Antonina, Vitali, Claudio
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - transplantation
Adipose tissue stem cells
Adult
Aged
Analysis
Antiulcer agents
Arthritis
Autografts - transplantation
Autologous fat grafting
Body fat
Care and treatment
Diabetes
Digital ulcers
Female
Fingers - pathology
Fingers - surgery
Follow-Up Studies
Humans
Hypoxia
Ischemia
Liposuction
Male
Middle Aged
Pain
Pain management
Prevalence studies (Epidemiology)
Scleroderma
Scleroderma (Disease)
Scleroderma, Systemic - diagnosis
Scleroderma, Systemic - surgery
Skin Ulcer - diagnosis
Skin Ulcer - surgery
Stem cells
Systemic sclerosis
Tissue Transplantation - methods
Transplants & implants
Treatment Outcome
Ulcers
Wound healing
Wound Healing - physiology
Young Adult
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Summary:A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healing in patients with systemic sclerosis (SSc). SSc patients with IDUs were randomized to be blindly treated with AT-G or a sham procedure (SP). AT-G consisted of injection, at the base of the finger with the IDU, of 0.5-1 ml AT after centrifugation of fat aspirate. The SP consisted of false liposuction and local injection of saline solution. The primary endpoint was to compare the cumulative prevalence of healed IDUs in the two groups within the following 8 weeks. AT-G and the SP were carried out in 25 and 13 patients, respectively. The two groups were comparable for age, gender, disease duration, and SSc subtypes. IDU healing was observed in 23/25 and 1/13 patients treated with AT-G and the SP, respectively (p 
ISSN:1478-6362
1478-6354
1478-6362
DOI:10.1186/s13075-018-1792-8