Gastrointestinal Tolerance and Protein Absorption Markers with a New Peptide Enteral Formula Compared to a Standard Intact Protein Enteral Formula in Critically Ill Patients

The aim of this exploratory study was to investigate gastrointestinal tolerance and protein absorption markers with a new enteral peptide formula (PF) compared to an isocaloric enteral intact protein standard formula (SF) containing the same amount of protein in ICU patients. Patients admitted to a...

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Bibliographic Details
Published in:Nutrients 2021-07, Vol.13 (7), p.2362
Main Authors: de Brito-Ashurst, Ione, Klebach, Marianne, Tsompanaki, Eleni, Kaul, Sundeep, van Horssen, Peter, Hofman, Zandrie
Format: Article
Language:English
Subjects:
Absorption
Chromatography
Constipation
Creatinine
Data collection
Defecation
Diarrhea
gastrointestinal tolerance
Hospital patients
hydrolyzed protein
ICU
Markers
Metabolism
Nitrogen
Nutrition
nutritional guidelines
Parenteral nutrition
Patients
Peptides
Phenols
Physiological aspects
polymeric formula
protein absorption
Protein turnover
Proteins
Statistical analysis
Thorax
Vomiting
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Summary:The aim of this exploratory study was to investigate gastrointestinal tolerance and protein absorption markers with a new enteral peptide formula (PF) compared to an isocaloric enteral intact protein standard formula (SF) containing the same amount of protein in ICU patients. Patients admitted to a cardio-thoracic intensive care unit expected to receive tube feeding for ≥5 days were randomized to receive either PF (1.5 kcal/mL) or SF in a double-blind manner for ≤14 days. Twenty-six patients were randomized (13 SF and 13 PF) and 23 (12 SF and 11 PF) completed at least 5 days of product administration. There were no statistically significant differences between the feeds during the first 5 days of intervention for diarrhea (SF:3 (23%); PF:5 (39%), p = 0.388), vomiting (SF:1 (8%); PF:2 (15%), p = 0.549), constipation (SF:7 (54%), PF:3 (23%), p = 0.115), and high gastric residual volume (>500 mL: SF:1 (8%); PF: 2 (15%), p = 0.535). There were no differences in plasma amino acids or urinary markers of protein absorption and metabolism. In conclusion, no major differences were found in tolerability and protein absorption markers between the standard intact protein formula and the peptide formula.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13072362