Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats

Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) leve...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.287-292-426
Main Authors: Alici, Ozlem, Kavakli, Havva Sahin, Koca, Cemile, Altintas, Neriman Defne, Aydin, Murat, Alici, Suleyman
Format: Article
Language:English
Subjects:
Acids
Animals
Antioxidants
Caffeic Acids - therapeutic use
Care and treatment
Cytokines
Disease Models, Animal
E coli
Endothelin-1 - blood
Esters
Free radicals
Gangrene
Health aspects
Infectious diseases
Inflammation - metabolism
Male
Malondialdehyde - metabolism
Medicine
Mortality
Oxidative Stress
Oxygen - chemistry
Phenols
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - therapeutic use
Random Allocation
Rats
Rats, Wistar
Rodents
Sepsis
Sepsis - drug therapy
Studies
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
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Summary:Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/810948