Extracellular signals regulate the biogenesis of extracellular vesicles

Extracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With various biomolecules and specific ligands, EV has represented a novel form of information transfer, which possesses extremely outstanding efficiency a...

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Published in:Biological research 2022-11, Vol.55 (1), p.1-35, Article 35
Main Authors: Jin, Yong, Ma, Lele, Zhang, Wanying, Yang, Wen, Feng, Qiyu, Wang, Hongyang
Format: Article
Language:English
Subjects:
BIOLOGY
Biosynthesis
Cellular signal transduction
Chromatography
Comparative analysis
Exosome
Extracellular signal
Extracellular vesicle
Extracellular vesicles
Information transfer
Lipids
Melanoma
Membrane vesicles
Microvesicle
Plasma
Proteins
Review
Signal transduction
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cited_by cdi_FETCH-LOGICAL-c613t-b816aad99990b6429d8690ef4f340098f088cfbc085308d7171656d5e3202f043
cites cdi_FETCH-LOGICAL-c613t-b816aad99990b6429d8690ef4f340098f088cfbc085308d7171656d5e3202f043
container_end_page 35
container_issue 1
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container_title Biological research
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creator Jin, Yong
Ma, Lele
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Yang, Wen
Feng, Qiyu
Wang, Hongyang
description Extracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With various biomolecules and specific ligands, EV has represented a novel form of information transfer, which possesses extremely outstanding efficiency and specificity compared to the classical signal transduction. In addition, EV has extended the concept of signal transduction to intercellular aspect by working as the collection of extracellular information. Therefore, the functions of EVs have been extensively characterized and EVs exhibit an exciting prospect for clinical applications. However, the biogenesis of EVs and, in particular, the regulation of this process by extracellular signals, which are essential to conduct further studies and support optimal utility, remain unclear. Here, we review the current understanding of the biogenesis of EVs, focus on the regulation of this process by extracellular signals and discuss their therapeutic value.
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source SciELO Chile; Publicly Available Content Database; Alma/SFX Local Collection
subjects BIOLOGY
Biosynthesis
Cellular signal transduction
Chromatography
Comparative analysis
Exosome
Extracellular signal
Extracellular vesicle
Extracellular vesicles
Information transfer
Lipids
Melanoma
Membrane vesicles
Microvesicle
Plasma
Proteins
Review
Signal transduction
title Extracellular signals regulate the biogenesis of extracellular vesicles
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