Cytokine profiling reveals increased serum inflammatory cytokines in idiopathic choroidal neovascularization

• Published in: BMC ophthalmology 2019-04, Vol.19 (1), p.94-94, Article 94
• Main Authors: Guo, Shenchao, Yin, Houfa, Zheng, Mingjie, Tang, Yizhen, Lu, Bing, Chen, Xinyi, Fu, Qiuli, Qin, Zhenwei, Lyu, Danni, Tang, Qiaomei, Zhang, Lifang, Ma, Jian, Zhang, Li, Fang, Xiaoyun
• Format: Article
• Language: English
• Subjects: Adult; Age; Angiogenesis; Biomarkers; Biomarkers - blood; Case-Control Studies; Choroidal Neovascularization - blood; Choroidal Neovascularization - physiopathology; Colony-stimulating factor; Cytokines; Cytokines - blood; Endothelial growth factors; Endothelium; Female; Fibroblast growth factor 2; Fibroblast growth factors; Fibroblasts; Granulocyte-macrophage colony-stimulating factor; Health care information services; Humans; Idiopathic choroidal neovascularization; Inflammation; Inflammation - physiopathology; Inflammatory cytokines; Interleukin 10; Interleukin 15; Interleukin 17; Interleukin 2; Interleukins; Macrophage colony stimulating factor; Macrophages; Macular degeneration; Male; Medical research; Medical schools; Middle Aged; Myopia; Neovascularization; Ophthalmology; Patients; Photodynamic therapy; Polymorphism; Ranibizumab; Retina; Retina - pathology; Serum; Serum levels; Statistical analysis; Tumor necrosis factor-TNF; Vascular endothelial growth factor; Vascularization; Visual Acuity - physiology
• ISSN: 1471-2415; 1471-2415
• DOI: 10.1186/s12886-019-1101-6

The exact pathogenesis of idiopathic choroidal neovascularization (ICNV) remains unclear. Cytokine-mediated inflammation has been thought to be involved in the pathophysiology of ICNV. The purpose of this study was to investigate serum cytokine profiles in patients with ICNV and to explore the relationship between serum cytokine levels and ICNV severity. This case-control study was conducted in 32 ICNV patients and 30 healthy volunteers. Clinical and demographic information was obtained from the medical data platform and the serum was analysed with a multiplex assay to determine the levels of seven cytokines: interleukin (IL)-2, IL-10, IL-15, IL-17, basic fibroblast growth factor (basic FGF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF). Serum levels of IL-2, IL-10, IL-17, basic FGF, and VEGF were elevated in ICNV patients compared to controls. Serum GM-CSF levels were positively related to central retinal thickness, and serum IL-17 levels were positively related to CNV lesion area. Serum inflammatory cytokines were significantly elevated in ICNV patients compared to controls. This suggests that systemic inflammation may play a critical role in the physiopathology of ICNV.