Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges

Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of...

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Bibliographic Details
Published in:npj Regenerative medicine 2017-08, Vol.2 (1), p.23-13, Article 23
Main Authors: Amer, Mahetab H., Rose, Felicity R. A. J., Shakesheff, Kevin M., Modo, Michel, White, Lisa J.
Format: Article
Language:English
Subjects:
631/378/1687
631/532/489
Accuracy
Apoptosis
Biomaterials
Biomedical and Life Sciences
Biomedicine
Cell Biology
Clinical trials
Drug dosages
Immunology
Medicine
Regenerative Medicine/Tissue Engineering
Retention
Review
Review Article
Spinal cord injuries
Stem Cells
Stroke
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Summary:Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell-therapy interventions.
ISSN:2057-3995
2057-3995
DOI:10.1038/s41536-017-0028-x