Rapid identification of Klebsiella pneumoniae and Serratia marcescens by surface-enhanced Raman spectroscopy

Two types of pathogenic bacteria, Klebsiella pneumoniae and Serratia marcescens, had been reported as important causes of hospital-acquired infection. Rapid and accurate identification of Klebsiella pneumoniae and Serratia marcescens is vitally important for the selection of appropriate treatment mo...

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Bibliographic Details
Published in:BIO web of conferences 2023-01, Vol.59, p.1019
Main Authors: Wu, Zhiwei, Ye, Qing, Wang, Xiaoyan, Zhang, Xianzeng, Xie, Shusen
Format: Article
Language:English
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Summary:Two types of pathogenic bacteria, Klebsiella pneumoniae and Serratia marcescens, had been reported as important causes of hospital-acquired infection. Rapid and accurate identification of Klebsiella pneumoniae and Serratia marcescens is vitally important for the selection of appropriate treatment modalities. In this article, the feasibility of using surface-enhanced Raman Spectroscopy (SERS) to identify Klebsiella pneumoniae and Serratia marcescens was explored. Spectrum samples were obtained from Klebsiella pneumoniae infections (n=1000) and Serratia marcescens infections (n=1000). The differences between the spectra of two types of pathogenic bacteria were also analyzed. Moreover, Principal Component Analysis- Linear Discriminant Analysis (PCA-LDA) algorithm was used to discriminate the spectra of pathogenic bacteria.
ISSN:2117-4458
2117-4458
DOI:10.1051/bioconf/20235901019