Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

• Published in: Environmental health 2024-01, Vol.23 (1), p.5-5, Article 5
• Main Authors: Ghozal, Manel, Kadawathagedara, Manik, Delvert, Rosalie, Divaret-Chauveau, Amandine, Raherison, Chantal, Varraso, Raphaëlle, Bédard, Annabelle, Crépet, Amélie, Sirot, Véronique, Charles, Marie Aline, Adel-Patient, Karine, de Lauzon-Guillain, Blandine
• Format: Article
• Language: English
• Subjects: Allergies; Allergy; Asthma; Asthma - chemically induced; Asthma - epidemiology; Birth cohort; Bisphenol A; Chemicals; Child, Preschool; Children & youth; Dermatitis; Diet; Dietary Exposure; Dietary Exposure - adverse effects; Dioxins; Eczema; Eczema - chemically induced; Eczema - epidemiology; Exposure; Female; Fluorocarbons; Food; Food allergies; Food allergy; Food and Nutrition; Food chemicals; Food contamination; Food Hypersensitivity; Furans; Hay fever; Health risks; Humans; Immune system; Life Sciences; Lung diseases; Medical research; Medicine, Experimental; Microbiota; Mixtures; Mothers; Parents & parenting; Pediatric respiratory diseases; Perfluoroalkyl & polyfluoroalkyl substances; Pesticides; Polycyclic Aromatic Hydrocarbons; Polycyclic Aromatic Hydrocarbons - adverse effects; Pregnancy; Pregnant women; Prenatal experience; Prenatal exposure; Respiration Disorders; Respiratory diseases; Respiratory Sounds; Respiratory Tract Diseases; Rhinitis; Risk; Santé publique et épidémiologie; Sensitivity analysis; Skin diseases; Toxicology; Toxicology and food chain; Trace Elements; Trace elements (nutrients); Wheezing
• ISSN: 1476-069X; 1476-069X
• DOI: 10.1186/s12940-023-01046-y

Prenatal exposure to environmental chemicals may be associated with allergies later in life. We aimed to examine the association between prenatal dietary exposure to mixtures of chemicals and allergic or respiratory diseases up to age 5.5 y. We included 11,638 mother-child pairs from the French "Étude Longitudinale Française depuis l'Enfance" (ELFE) cohort. Maternal dietary exposure during pregnancy to eight mixtures of chemicals was previously assessed. Allergic and respiratory diseases (eczema, food allergy, wheezing and asthma) were reported by parents between birth and age 5.5 years. Associations were evaluated with adjusted logistic regressions. Results are expressed as odds ratio (OR[95%CI]) for a variation of one SD increase in mixture pattern. Maternal dietary exposure to a mixture composed mainly of trace elements, furans and polycyclic aromatic hydrocarbons (PAHs) was positively associated with the risk of eczema (1.10 [1.05; 1.15]), this association was consistent across sensitivity analyses. Dietary exposure to one mixture of pesticides was positively associated with the risk of food allergy (1.10 [1.02; 1.18]), whereas the exposure to another mixture of pesticides was positively but slightly related to the risk of wheezing (1.05 [1.01; 1.08]). This last association was not found in all sensitivity analyses. Dietary exposure to a mixture composed by perfluoroalkyl acids, PAHs and trace elements was negatively associated with the risk of asthma (0.89 [0.80; 0.99]), this association was consistent across sensitivity analyses, except the complete-case analysis. Whereas few individual chemicals were related to the risk of allergic and respiratory diseases, some consistent associations were found between prenatal dietary exposure to some mixtures of chemicals and the risk of allergic or respiratory diseases. The positive association between trace elements, furans and PAHs and the risk of eczema, and that between pesticides mixtures and food allergy need to be confirmed in other studies. Conversely, the negative association between perfluoroalkyl acids, PAHs and trace elements and the risk of asthma need to be further explored.