The emerging roles of ferroptosis in cells of the central nervous system

Ferroptosis is morphologically characterized by shrunken mitochondria and biochemically characterized by iron overload, lipid peroxidation and lipid reactive oxygen species (ROS) accumulation; these phenomena are suppressed by iron chelation, genetic inhibition of cellular iron uptake, and intervent...

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Bibliographic Details
Published in:Frontiers in neuroscience 2022-12, Vol.16, p.1032140-1032140
Main Authors: Li, Yuyao, Xiao, Dongqiong, Wang, Xiaodong
Format: Article
Language:English
Subjects:
Amino acids
Antioxidants
Apoptosis
astrocyte
Autophagy
Biosynthesis
Brain
Central nervous system
Chelation
Enzymes
Fatty acids
Ferroptosis
Glial cells
Iron
Lipid metabolism
Lipid peroxidation
Lipids
Membranes
Metabolism
microglia
Mitochondria
Morphology
Nervous system
Neurological diseases
Neuronal-glial interactions
Neuroscience
oligodendrocyte
pericyte
Pericytes
Proteins
Reactive oxygen species
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Summary:Ferroptosis is morphologically characterized by shrunken mitochondria and biochemically characterized by iron overload, lipid peroxidation and lipid reactive oxygen species (ROS) accumulation; these phenomena are suppressed by iron chelation, genetic inhibition of cellular iron uptake, and intervention on other pathways such as lipid metabolism. The induction of ferroptosis may be related to pathological cellular conditions in the central nervous system (CNS); thus, ferroptosis may cause disability via CNS damage. Here, we review the role of ferroptosis in the main cells of the CNS, including glial cells, neurons, and pericytes; in various diseases of the CNS; and in the interaction of glia and neurons in CNS diseases. Some small molecules and traditional Chinese drugs which inhibit ferroptosis in cells of the CNS are shown as potential therapeutic strategies for neurological diseases.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2022.1032140