Platelet transfusion: basic aspects

Platelet transfusions have been shown to prevent major haemorrhage and improve survival in thrombocytopenic patients. Since then, advances in the preparation of platelet components, including the introduction of pathogen reduction techniques, have been achieved. The number of transfused platelet com...

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Bibliographic Details
Published in:Swiss medical weekly 2013-12, Vol.143 (4950), p.w13885-w13885
Main Authors: Holbro, Andreas, Infanti, Laura, Sigle, Jörg, Buser, Andreas
Format: Article
Language:English
Subjects:
Blood Donors
Communicable Disease Control - methods
Gamma Rays
Hemorrhage - prevention & control
Humans
Platelet Transfusion - methods
Plateletpheresis - methods
platelets
Thrombocytopenia - therapy
Transfusion
Ultraviolet Rays
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Summary:Platelet transfusions have been shown to prevent major haemorrhage and improve survival in thrombocytopenic patients. Since then, advances in the preparation of platelet components, including the introduction of pathogen reduction techniques, have been achieved. The number of transfused platelet components is still growing owing to the increasing number of patients treated for haemato-oncological diseases. Additionally, indications have been extended, for example to patients with drug-induced platelet dysfunction. This review focuses on current platelet component production and storage techniques, including pathogen reduction, indications for platelet transfusion and safety issues including alloimmunisation and management of platelet refractoriness.
ISSN:1424-7860
1424-3997
DOI:10.4414/smw.2013.13885