Noninvasive Monitoring Strategies for Bronchopulmonary Dysplasia or Post-Prematurity Respiratory Disease: Current Challenges and Future Prospects

Definitions of bronchopulmonary dysplasia (BPD) or post-prematurity respiratory disease (PPRD) aim to stratify the risk of mortality and morbidity, with an emphasis on long-term respiratory outcomes. There is no univocal classification of BPD due to its complex multifactorial nature and the substant...

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Bibliographic Details
Published in:Children (Basel) 2023-10, Vol.10 (11), p.1753
Main Authors: Zini, Tommaso, Miselli, Francesca, Berardi, Alberto
Format: Article
Language:English
Subjects:
Apgar score
Biomarkers
Birth weight
Bronchopulmonary dysplasia
Chronic obstructive pulmonary disease
Clinical decision making
Decision-making
Epigenetics
Genomics
Gestational age
Hypertension
Infants (Premature)
Intubation
Iran
Lung diseases
lung oxygenation
Lungs
Medical prognosis
Medicine, Preventive
Mortality
near-infrared spectroscopy
Neonatology
Newborn babies
Nitric oxide
noninvasive monitoring
post-prematurity respiratory disease
Premature babies
Premature birth
preterm infants
Preventive health services
Proteomics
Respiratory diseases
Respiratory distress syndrome
Risk factors
Stem cells
Surfactants
Systematic review
Transplantation
Ventilators
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Summary:Definitions of bronchopulmonary dysplasia (BPD) or post-prematurity respiratory disease (PPRD) aim to stratify the risk of mortality and morbidity, with an emphasis on long-term respiratory outcomes. There is no univocal classification of BPD due to its complex multifactorial nature and the substantial heterogeneity of clinical presentation. Currently, there is no definitive treatment available for extremely premature very-low-birth-weight infants with BPD, and challenges in finding targeted preventive therapies persist. However, innovative stem cell-based postnatal therapies targeting BPD-free survival are emerging, which are likely to be offered in the first few days of life to high-risk premature infants. Hence, we need easy-to-use noninvasive tools for a standardized, precise, and reliable BPD assessment at a very early stage, to support clinical decision-making and to predict the response to treatment. In this non-systematic review, we present an overview of strategies for monitoring preterm infants with early and evolving BPD-PPRD, and we make some remarks on future prospects, with a focus on near-infrared spectroscopy (NIRS).
ISSN:2227-9067
2227-9067
DOI:10.3390/children10111753