Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case–control study

Background and Aim Dehydroepiandrosterone (DHEA) has a protective role against several types of cancer, although its mechanisms of action are still unknown, it may be related to the antioxidant effect of DHEA. We hypothesized that DHEA has a preventive effect on the formation of the 8‐hydroxy‐2′‐deo...

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Bibliographic Details
Published in:JGH open 2021-08, Vol.5 (8), p.902-906
Main Authors: Fazli, Hamid Reza, Mohamadkhani, Ashraf, Godarzi, Hamed Reza, Pourshams, Akram, Jafari Nia, Mojtaba
Format: Article
Language:English
Subjects:
8‐hydroxy‐2‐deoxyguanosine
Body mass index
dehydroepiandrosterone
Diabetes
DNA damage
Original
Pancreatic cancer
Values
Variables
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Summary:Background and Aim Dehydroepiandrosterone (DHEA) has a protective role against several types of cancer, although its mechanisms of action are still unknown, it may be related to the antioxidant effect of DHEA. We hypothesized that DHEA has a preventive effect on the formation of the 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) DNA adduct in pancreatic cancer patients. Methods Serum DHEAs were quantified by the ELISA method in 50 pancreatic cancer patients with histopathological diagnosis of adenocarcinoma and 50 matched controls. The amount of 8‐OHdG was assessed in peripheral blood leukocyte extracted DNA using a 32P‐DNA postlabeling technique. Results Pancreatic cancer patients had lower serum DHEA levels than healthy controls, although it did not differ significantly. Instead, the 8‐OHdG DNA adduct was significantly higher in the case than in the control (P = 
ISSN:2397-9070
2397-9070
DOI:10.1002/jgh3.12604