Evaluation of mean platelet volume in localized scleroderma

Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. To eval...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2017-09, Vol.92 (5), p.635-637
Main Authors: Bahali, Anil Gulsel, Su, Ozlem, Emiroglu, Nazan, Cengiz, Fatma Pelin, Kaya, Mehmet Onur, Onsun, Nahide
Format: Article
Language:English
Subjects:
Blood platelets
DERMATOLOGY
Investigation
Scleroderma, localized
Transforming growth factor beta
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Summary:Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. To evaluate whether there was any relation between localized scleroderma and platelet parameters. Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p
ISSN:0365-0596
1806-4841
1806-4841
0365-0596
DOI:10.1590/abd1806-4841.20176045