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Evaluation of mean platelet volume in localized scleroderma
Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. To eval...
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| Published in: | Anais brasileiros de dermatología 2017-09, Vol.92 (5), p.635-637 |
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| creator | Bahali, Anil Gulsel Su, Ozlem Emiroglu, Nazan Cengiz, Fatma Pelin Kaya, Mehmet Onur Onsun, Nahide |
| description | Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation.
To evaluate whether there was any relation between localized scleroderma and platelet parameters.
Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects.
The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p |
| doi_str_mv | 10.1590/abd1806-4841.20176045 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_db40666b4b224e3985b561a4fd7ab771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S0365_05962017000500635</scielo_id><doaj_id>oai_doaj_org_article_db40666b4b224e3985b561a4fd7ab771</doaj_id><sourcerecordid>1967863032</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-6f772a308023f19b64943c65df1fe1e4c035503292b1fbea88f1ec841965e4813</originalsourceid><addsrcrecordid>eNpVUV2L1DAUDaK44-hPUProS8eb5qMNgiDLqgsLPqjPIUlv1g5pMybtgP56U2d2cJ8CN_ecez4IeU1hR4WCd8b2tANZ847TXQO0lcDFE7K5DJ-SDTApahBKXpEXOe8BGq5a9ZxcNYpKyVW3Ie9vjiYsZh7iVEVfjWim6hDMjAHn6hjDMmI1TFWIzoThD_ZVdgFT7DGN5iV55k3I-Or8bsmPTzffr7_Ud18_315_vKudoHKupW_bxjDooGGeKlsOc-ak6D31SJE7YEIAa1Rjqbdous5TdMWBkgJ5R9mW3J54-2j2-pCG0aTfOppB_xvEdK9NmociTPeWg5TScts0HJnqhBWSGu771ti2Xbl2J67sBgxR7-OSpiJef1vD0mtYa5gAIAAkEwXw4QQ4LHbE3uE0JxMeqXj8Mw0_9X08aiFbLovTLXl7Jkjx14J51uOQHYZgJoxL1sVm20lWAiir4rTqUsw5ob-coaDX1vW5db0WrB9aL7g3_2u8oB5qZn8BLFqlsw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1967863032</pqid></control><display><type>article</type><title>Evaluation of mean platelet volume in localized scleroderma</title><source>SciELO</source><source>PubMed Central</source><creator>Bahali, Anil Gulsel ; Su, Ozlem ; Emiroglu, Nazan ; Cengiz, Fatma Pelin ; Kaya, Mehmet Onur ; Onsun, Nahide</creator><creatorcontrib>Bahali, Anil Gulsel ; Su, Ozlem ; Emiroglu, Nazan ; Cengiz, Fatma Pelin ; Kaya, Mehmet Onur ; Onsun, Nahide</creatorcontrib><description>Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation.
To evaluate whether there was any relation between localized scleroderma and platelet parameters.
Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects.
The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01).
The limited number of patients and the retrospective nature of the study were our limitations.
This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies.</description><identifier>ISSN: 0365-0596</identifier><identifier>ISSN: 1806-4841</identifier><identifier>EISSN: 1806-4841</identifier><identifier>EISSN: 0365-0596</identifier><identifier>DOI: 10.1590/abd1806-4841.20176045</identifier><identifier>PMID: 29166498</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Dermatologia</publisher><subject>Blood platelets ; DERMATOLOGY ; Investigation ; Scleroderma, localized ; Transforming growth factor beta</subject><ispartof>Anais brasileiros de dermatología, 2017-09, Vol.92 (5), p.635-637</ispartof><rights>2017 by Anais Brasileiros de Dermatologia 2017 Anais Brasileiros de Dermatologia</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-6f772a308023f19b64943c65df1fe1e4c035503292b1fbea88f1ec841965e4813</citedby><cites>FETCH-LOGICAL-c516t-6f772a308023f19b64943c65df1fe1e4c035503292b1fbea88f1ec841965e4813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674694/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674694/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,24130,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29166498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahali, Anil Gulsel</creatorcontrib><creatorcontrib>Su, Ozlem</creatorcontrib><creatorcontrib>Emiroglu, Nazan</creatorcontrib><creatorcontrib>Cengiz, Fatma Pelin</creatorcontrib><creatorcontrib>Kaya, Mehmet Onur</creatorcontrib><creatorcontrib>Onsun, Nahide</creatorcontrib><title>Evaluation of mean platelet volume in localized scleroderma</title><title>Anais brasileiros de dermatología</title><addtitle>An Bras Dermatol</addtitle><description>Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation.
To evaluate whether there was any relation between localized scleroderma and platelet parameters.
Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects.
The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01).
The limited number of patients and the retrospective nature of the study were our limitations.
This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies.</description><subject>Blood platelets</subject><subject>DERMATOLOGY</subject><subject>Investigation</subject><subject>Scleroderma, localized</subject><subject>Transforming growth factor beta</subject><issn>0365-0596</issn><issn>1806-4841</issn><issn>1806-4841</issn><issn>0365-0596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVUV2L1DAUDaK44-hPUProS8eb5qMNgiDLqgsLPqjPIUlv1g5pMybtgP56U2d2cJ8CN_ecez4IeU1hR4WCd8b2tANZ847TXQO0lcDFE7K5DJ-SDTApahBKXpEXOe8BGq5a9ZxcNYpKyVW3Ie9vjiYsZh7iVEVfjWim6hDMjAHn6hjDMmI1TFWIzoThD_ZVdgFT7DGN5iV55k3I-Or8bsmPTzffr7_Ud18_315_vKudoHKupW_bxjDooGGeKlsOc-ak6D31SJE7YEIAa1Rjqbdous5TdMWBkgJ5R9mW3J54-2j2-pCG0aTfOppB_xvEdK9NmociTPeWg5TScts0HJnqhBWSGu771ti2Xbl2J67sBgxR7-OSpiJef1vD0mtYa5gAIAAkEwXw4QQ4LHbE3uE0JxMeqXj8Mw0_9X08aiFbLovTLXl7Jkjx14J51uOQHYZgJoxL1sVm20lWAiir4rTqUsw5ob-coaDX1vW5db0WrB9aL7g3_2u8oB5qZn8BLFqlsw</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Bahali, Anil Gulsel</creator><creator>Su, Ozlem</creator><creator>Emiroglu, Nazan</creator><creator>Cengiz, Fatma Pelin</creator><creator>Kaya, Mehmet Onur</creator><creator>Onsun, Nahide</creator><general>Sociedade Brasileira de Dermatologia</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>20170901</creationdate><title>Evaluation of mean platelet volume in localized scleroderma</title><author>Bahali, Anil Gulsel ; Su, Ozlem ; Emiroglu, Nazan ; Cengiz, Fatma Pelin ; Kaya, Mehmet Onur ; Onsun, Nahide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-6f772a308023f19b64943c65df1fe1e4c035503292b1fbea88f1ec841965e4813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Blood platelets</topic><topic>DERMATOLOGY</topic><topic>Investigation</topic><topic>Scleroderma, localized</topic><topic>Transforming growth factor beta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahali, Anil Gulsel</creatorcontrib><creatorcontrib>Su, Ozlem</creatorcontrib><creatorcontrib>Emiroglu, Nazan</creatorcontrib><creatorcontrib>Cengiz, Fatma Pelin</creatorcontrib><creatorcontrib>Kaya, Mehmet Onur</creatorcontrib><creatorcontrib>Onsun, Nahide</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Anais brasileiros de dermatología</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahali, Anil Gulsel</au><au>Su, Ozlem</au><au>Emiroglu, Nazan</au><au>Cengiz, Fatma Pelin</au><au>Kaya, Mehmet Onur</au><au>Onsun, Nahide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of mean platelet volume in localized scleroderma</atitle><jtitle>Anais brasileiros de dermatología</jtitle><addtitle>An Bras Dermatol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>92</volume><issue>5</issue><spage>635</spage><epage>637</epage><pages>635-637</pages><issn>0365-0596</issn><issn>1806-4841</issn><eissn>1806-4841</eissn><eissn>0365-0596</eissn><abstract>Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation.
To evaluate whether there was any relation between localized scleroderma and platelet parameters.
Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects.
The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01).
The limited number of patients and the retrospective nature of the study were our limitations.
This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Dermatologia</pub><pmid>29166498</pmid><doi>10.1590/abd1806-4841.20176045</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Blood platelets DERMATOLOGY Investigation Scleroderma, localized Transforming growth factor beta |
| title | Evaluation of mean platelet volume in localized scleroderma |
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