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Consanguineous marriages and endemic malaria: can inbreeding increase population fitness?
The practice of consanguineous marriages is widespread in countries with endemic malaria. In these regions, consanguinity increases the prevalence of alpha+-thalassemia, which is protective against malaria. However, it also causes an excessive mortality amongst the offspring due to an increase in ho...
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Published in: | Malaria journal 2008-08, Vol.7 (1), p.150-150, Article 150 |
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description | The practice of consanguineous marriages is widespread in countries with endemic malaria. In these regions, consanguinity increases the prevalence of alpha+-thalassemia, which is protective against malaria. However, it also causes an excessive mortality amongst the offspring due to an increase in homozygosis of recessive lethal alleles. The aim of this study was to explore the overall effects of inbreeding on the fitness of a population infested with malaria.
In a stochastic computer model of population growth, the sizes of inbred and outbred populations were compared. The model has been previously validated producing results for inbred populations that have agreed with analytical predictions. Survival likelihoods for different alpha+-thalassemia genotypes were obtained from the odds of severe forms of disease from a field study. Survivals were further estimated for different values of mortality from malaria.
Inbreeding increases the frequency of alpha+-thalassemia allele and the loss of life due to homozygosis of recessive lethal alleles; both are proportional to the coefficient of inbreeding and the frequency of alleles in population. Inbreeding-mediated decrease in mortality from malaria (produced via enhanced alpha+-thalassemia frequency) mitigates inbreeding-related increases in fatality (produced via increased homozygosity of recessive lethals). When the death rate due to malaria is high, the net effect of inbreeding is a reduction in the overall mortality of the population.
Consanguineous marriages may increase the overall fitness of populations with endemic malaria. |
doi_str_mv | 10.1186/1475-2875-7-150 |
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In a stochastic computer model of population growth, the sizes of inbred and outbred populations were compared. The model has been previously validated producing results for inbred populations that have agreed with analytical predictions. Survival likelihoods for different alpha+-thalassemia genotypes were obtained from the odds of severe forms of disease from a field study. Survivals were further estimated for different values of mortality from malaria.
Inbreeding increases the frequency of alpha+-thalassemia allele and the loss of life due to homozygosis of recessive lethal alleles; both are proportional to the coefficient of inbreeding and the frequency of alleles in population. Inbreeding-mediated decrease in mortality from malaria (produced via enhanced alpha+-thalassemia frequency) mitigates inbreeding-related increases in fatality (produced via increased homozygosity of recessive lethals). When the death rate due to malaria is high, the net effect of inbreeding is a reduction in the overall mortality of the population.
Consanguineous marriages may increase the overall fitness of populations with endemic malaria.</description><identifier>ISSN: 1475-2875</identifier><identifier>EISSN: 1475-2875</identifier><identifier>DOI: 10.1186/1475-2875-7-150</identifier><identifier>PMID: 18673576</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>alpha-Thalassemia - genetics ; Consanguinity ; Distribution ; Endemic Diseases - prevention & control ; Gene Frequency ; Genetics, Population ; Health aspects ; Homozygote ; Humans ; Malaria ; Malaria - epidemiology ; Malaria - genetics ; Models, Theoretical ; Prevalence studies (Epidemiology) ; Risk factors</subject><ispartof>Malaria journal, 2008-08, Vol.7 (1), p.150-150, Article 150</ispartof><rights>COPYRIGHT 2008 BioMed Central Ltd.</rights><rights>Copyright © 2008 Denic et al; licensee BioMed Central Ltd. 2008 Denic et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b586t-43caab940af83128c2065b44fbe7f9eba6d8955e5d8b7273a91b93e6d5d1fc823</citedby><cites>FETCH-LOGICAL-b586t-43caab940af83128c2065b44fbe7f9eba6d8955e5d8b7273a91b93e6d5d1fc823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527611/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527611/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18673576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Denic, Srdjan</creatorcontrib><creatorcontrib>Nagelkerke, Nicolas</creatorcontrib><creatorcontrib>Agarwal, Mukesh M</creatorcontrib><title>Consanguineous marriages and endemic malaria: can inbreeding increase population fitness?</title><title>Malaria journal</title><addtitle>Malar J</addtitle><description>The practice of consanguineous marriages is widespread in countries with endemic malaria. In these regions, consanguinity increases the prevalence of alpha+-thalassemia, which is protective against malaria. However, it also causes an excessive mortality amongst the offspring due to an increase in homozygosis of recessive lethal alleles. The aim of this study was to explore the overall effects of inbreeding on the fitness of a population infested with malaria.
In a stochastic computer model of population growth, the sizes of inbred and outbred populations were compared. The model has been previously validated producing results for inbred populations that have agreed with analytical predictions. Survival likelihoods for different alpha+-thalassemia genotypes were obtained from the odds of severe forms of disease from a field study. Survivals were further estimated for different values of mortality from malaria.
Inbreeding increases the frequency of alpha+-thalassemia allele and the loss of life due to homozygosis of recessive lethal alleles; both are proportional to the coefficient of inbreeding and the frequency of alleles in population. Inbreeding-mediated decrease in mortality from malaria (produced via enhanced alpha+-thalassemia frequency) mitigates inbreeding-related increases in fatality (produced via increased homozygosity of recessive lethals). When the death rate due to malaria is high, the net effect of inbreeding is a reduction in the overall mortality of the population.
Consanguineous marriages may increase the overall fitness of populations with endemic malaria.</description><subject>alpha-Thalassemia - genetics</subject><subject>Consanguinity</subject><subject>Distribution</subject><subject>Endemic Diseases - prevention & control</subject><subject>Gene Frequency</subject><subject>Genetics, Population</subject><subject>Health aspects</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Malaria</subject><subject>Malaria - epidemiology</subject><subject>Malaria - genetics</subject><subject>Models, Theoretical</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Risk factors</subject><issn>1475-2875</issn><issn>1475-2875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFUkuLFDEQbkRxH3r2Jn3yNruddJ4elHVwdWHBix48hUq60mbpScakZ8F_b-bBugOKBJLiq6ovVfVV07wi3QUhSlwSJvmCqnrJBeHdk-b0AXn6yD5pzkq56zoilaTPm5OaKnsuxWnzfZligThuQsS0Ke0Kcg4wYmkhDi3GAVfBVXSCCr9tHcQ2RJsRhxDHarqMULBdp_Vmgjmk2PowRyzl_YvmmYep4MvDe958u_74dfl5cfvl083y6nZhuRLzgvUOwGrWgVc9ocrRTnDLmLcovUYLYlCac-SDspLKHjSxukcx8IF4p2h_3tzseYcEd2adQ23hl0kQzA5IeTSQ5-AmNINlQCjpibWWEe51p4VgwlPdWculr1zv9lzrjV3h4DDOGaYj0mNPDD_MmO4N5VQKQirBhz2BDekfBMcel1ZmK5PZymSkqSJWkjeHKnL6ucEym1UoDqcJdhoZoZmmTPb_DSS1PSkkq4EX-8AR6hhC9Kl-7urZyZsi-lDxK6IY1UqqbR-X-wSXUykZ_UMLpDPbzftL0a8fj-5P_GHV-t_-I9Xm</recordid><startdate>20080802</startdate><enddate>20080802</enddate><creator>Denic, Srdjan</creator><creator>Nagelkerke, Nicolas</creator><creator>Agarwal, Mukesh M</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20080802</creationdate><title>Consanguineous marriages and endemic malaria: can inbreeding increase population fitness?</title><author>Denic, Srdjan ; Nagelkerke, Nicolas ; Agarwal, Mukesh M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b586t-43caab940af83128c2065b44fbe7f9eba6d8955e5d8b7273a91b93e6d5d1fc823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>alpha-Thalassemia - genetics</topic><topic>Consanguinity</topic><topic>Distribution</topic><topic>Endemic Diseases - prevention & control</topic><topic>Gene Frequency</topic><topic>Genetics, Population</topic><topic>Health aspects</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Malaria</topic><topic>Malaria - epidemiology</topic><topic>Malaria - genetics</topic><topic>Models, Theoretical</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Denic, Srdjan</creatorcontrib><creatorcontrib>Nagelkerke, Nicolas</creatorcontrib><creatorcontrib>Agarwal, Mukesh M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Malaria journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Denic, Srdjan</au><au>Nagelkerke, Nicolas</au><au>Agarwal, Mukesh M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consanguineous marriages and endemic malaria: can inbreeding increase population fitness?</atitle><jtitle>Malaria journal</jtitle><addtitle>Malar J</addtitle><date>2008-08-02</date><risdate>2008</risdate><volume>7</volume><issue>1</issue><spage>150</spage><epage>150</epage><pages>150-150</pages><artnum>150</artnum><issn>1475-2875</issn><eissn>1475-2875</eissn><abstract>The practice of consanguineous marriages is widespread in countries with endemic malaria. In these regions, consanguinity increases the prevalence of alpha+-thalassemia, which is protective against malaria. However, it also causes an excessive mortality amongst the offspring due to an increase in homozygosis of recessive lethal alleles. The aim of this study was to explore the overall effects of inbreeding on the fitness of a population infested with malaria.
In a stochastic computer model of population growth, the sizes of inbred and outbred populations were compared. The model has been previously validated producing results for inbred populations that have agreed with analytical predictions. Survival likelihoods for different alpha+-thalassemia genotypes were obtained from the odds of severe forms of disease from a field study. Survivals were further estimated for different values of mortality from malaria.
Inbreeding increases the frequency of alpha+-thalassemia allele and the loss of life due to homozygosis of recessive lethal alleles; both are proportional to the coefficient of inbreeding and the frequency of alleles in population. Inbreeding-mediated decrease in mortality from malaria (produced via enhanced alpha+-thalassemia frequency) mitigates inbreeding-related increases in fatality (produced via increased homozygosity of recessive lethals). When the death rate due to malaria is high, the net effect of inbreeding is a reduction in the overall mortality of the population.
Consanguineous marriages may increase the overall fitness of populations with endemic malaria.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>18673576</pmid><doi>10.1186/1475-2875-7-150</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | alpha-Thalassemia - genetics Consanguinity Distribution Endemic Diseases - prevention & control Gene Frequency Genetics, Population Health aspects Homozygote Humans Malaria Malaria - epidemiology Malaria - genetics Models, Theoretical Prevalence studies (Epidemiology) Risk factors |
title | Consanguineous marriages and endemic malaria: can inbreeding increase population fitness? |
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