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Inflammation and Elevated Osteopontin in Plasma and CSF in Cerebral Malaria Compared to Plasmodium -Negative Neurological Infections
Cerebral malaria in young African children is associated with high mortality, and persisting neurological deficits often remain in survivors. Sequestered -infected red blood cells lead to cerebrovascular inflammation and subsequent neuroinflammation. Brain inflammation can play a role in the pathoge...
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Published in: | International journal of molecular sciences 2024-09, Vol.25 (17), p.9620 |
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description | Cerebral malaria in young African children is associated with high mortality, and persisting neurological deficits often remain in survivors. Sequestered
-infected red blood cells lead to cerebrovascular inflammation and subsequent neuroinflammation. Brain inflammation can play a role in the pathogenesis of neurologic sequelae. Therefore, we assessed a select set of proinflammatory analytes (IP10, IL23, MIP3α, GRO, MCP-1, and osteopontin in both the plasma and cerebrospinal fluid(CSF) of Zambian children with cerebral malaria and compared this with children with neurological symptoms that were negative for
(non-cerebral malaria). Several similarities in plasma and CSF levels were found, as were some striking differences. We confirmed that IP10 levels were higher in the plasma of cerebral malaria patients, but this was not found in CSF. Levels of osteopontin were elevated in both the plasma and CSF of CM patients compared to the non-CM patients. These results show again a highly inflammatory environment in both groups but a different profile for CM when compared to non-cerebral malaria. Osteopontin may play an important role in neurological inflammation in CM and the resulting sequelae. Therefore, osteopontin could be a valid target for further biomarker research and potentially for therapeutic interventions in neuroinflammatory infections. |
doi_str_mv | 10.3390/ijms25179620 |
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-infected red blood cells lead to cerebrovascular inflammation and subsequent neuroinflammation. Brain inflammation can play a role in the pathogenesis of neurologic sequelae. Therefore, we assessed a select set of proinflammatory analytes (IP10, IL23, MIP3α, GRO, MCP-1, and osteopontin in both the plasma and cerebrospinal fluid(CSF) of Zambian children with cerebral malaria and compared this with children with neurological symptoms that were negative for
(non-cerebral malaria). Several similarities in plasma and CSF levels were found, as were some striking differences. We confirmed that IP10 levels were higher in the plasma of cerebral malaria patients, but this was not found in CSF. Levels of osteopontin were elevated in both the plasma and CSF of CM patients compared to the non-CM patients. These results show again a highly inflammatory environment in both groups but a different profile for CM when compared to non-cerebral malaria. Osteopontin may play an important role in neurological inflammation in CM and the resulting sequelae. Therefore, osteopontin could be a valid target for further biomarker research and potentially for therapeutic interventions in neuroinflammatory infections.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25179620</identifier><identifier>PMID: 39273566</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bacterial infections ; Biomarkers - blood ; Biomarkers - cerebrospinal fluid ; Blood ; cerebral malaria ; Chemokines ; Child ; Child, Preschool ; Encephalitis ; Female ; GRO ; Humans ; Infant ; Infections ; Inflammation ; Inflammation - blood ; Inflammation - cerebrospinal fluid ; IP10 ; Malaria ; Malaria, Cerebral - blood ; Malaria, Cerebral - cerebrospinal fluid ; Malaria, Cerebral - parasitology ; Malaria, Falciparum - blood ; Malaria, Falciparum - cerebrospinal fluid ; Malaria, Falciparum - parasitology ; Male ; Meningitis ; Mortality ; Neurons ; osteopontin ; Osteopontin - blood ; Osteopontin - cerebrospinal fluid ; Patients ; Plasma ; Plasmodium falciparum - pathogenicity ; Proteins ; Viral infections ; West Nile virus</subject><ispartof>International journal of molecular sciences, 2024-09, Vol.25 (17), p.9620</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-4e8cf9e90a43378c4943bfa5be4a4ba88480d25eee7938189334753ed17b742d3</cites><orcidid>0000-0003-1149-8193 ; 0000-0002-4128-5335</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3104099490?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3104099490?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,38516,43895,44590,74412,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39273566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stins, Monique F</creatorcontrib><creatorcontrib>Mtaja, Agnes</creatorcontrib><creatorcontrib>Mulendele, Evans</creatorcontrib><creatorcontrib>Mwimbe, Daniel</creatorcontrib><creatorcontrib>Pinilla-Monsalve, Gabriel D</creatorcontrib><creatorcontrib>Mutengo, Mable</creatorcontrib><creatorcontrib>Pardo, Carlos A</creatorcontrib><creatorcontrib>Chipeta, James</creatorcontrib><title>Inflammation and Elevated Osteopontin in Plasma and CSF in Cerebral Malaria Compared to Plasmodium -Negative Neurological Infections</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Cerebral malaria in young African children is associated with high mortality, and persisting neurological deficits often remain in survivors. Sequestered
-infected red blood cells lead to cerebrovascular inflammation and subsequent neuroinflammation. Brain inflammation can play a role in the pathogenesis of neurologic sequelae. Therefore, we assessed a select set of proinflammatory analytes (IP10, IL23, MIP3α, GRO, MCP-1, and osteopontin in both the plasma and cerebrospinal fluid(CSF) of Zambian children with cerebral malaria and compared this with children with neurological symptoms that were negative for
(non-cerebral malaria). Several similarities in plasma and CSF levels were found, as were some striking differences. We confirmed that IP10 levels were higher in the plasma of cerebral malaria patients, but this was not found in CSF. Levels of osteopontin were elevated in both the plasma and CSF of CM patients compared to the non-CM patients. These results show again a highly inflammatory environment in both groups but a different profile for CM when compared to non-cerebral malaria. Osteopontin may play an important role in neurological inflammation in CM and the resulting sequelae. Therefore, osteopontin could be a valid target for further biomarker research and potentially for therapeutic interventions in neuroinflammatory infections.</description><subject>Bacterial infections</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Blood</subject><subject>cerebral malaria</subject><subject>Chemokines</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Encephalitis</subject><subject>Female</subject><subject>GRO</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - cerebrospinal fluid</subject><subject>IP10</subject><subject>Malaria</subject><subject>Malaria, Cerebral - blood</subject><subject>Malaria, Cerebral - cerebrospinal fluid</subject><subject>Malaria, Cerebral - parasitology</subject><subject>Malaria, Falciparum - blood</subject><subject>Malaria, Falciparum - 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Sequestered
-infected red blood cells lead to cerebrovascular inflammation and subsequent neuroinflammation. Brain inflammation can play a role in the pathogenesis of neurologic sequelae. Therefore, we assessed a select set of proinflammatory analytes (IP10, IL23, MIP3α, GRO, MCP-1, and osteopontin in both the plasma and cerebrospinal fluid(CSF) of Zambian children with cerebral malaria and compared this with children with neurological symptoms that were negative for
(non-cerebral malaria). Several similarities in plasma and CSF levels were found, as were some striking differences. We confirmed that IP10 levels were higher in the plasma of cerebral malaria patients, but this was not found in CSF. Levels of osteopontin were elevated in both the plasma and CSF of CM patients compared to the non-CM patients. These results show again a highly inflammatory environment in both groups but a different profile for CM when compared to non-cerebral malaria. Osteopontin may play an important role in neurological inflammation in CM and the resulting sequelae. Therefore, osteopontin could be a valid target for further biomarker research and potentially for therapeutic interventions in neuroinflammatory infections.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39273566</pmid><doi>10.3390/ijms25179620</doi><orcidid>https://orcid.org/0000-0003-1149-8193</orcidid><orcidid>https://orcid.org/0000-0002-4128-5335</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Bacterial infections Biomarkers - blood Biomarkers - cerebrospinal fluid Blood cerebral malaria Chemokines Child Child, Preschool Encephalitis Female GRO Humans Infant Infections Inflammation Inflammation - blood Inflammation - cerebrospinal fluid IP10 Malaria Malaria, Cerebral - blood Malaria, Cerebral - cerebrospinal fluid Malaria, Cerebral - parasitology Malaria, Falciparum - blood Malaria, Falciparum - cerebrospinal fluid Malaria, Falciparum - parasitology Male Meningitis Mortality Neurons osteopontin Osteopontin - blood Osteopontin - cerebrospinal fluid Patients Plasma Plasmodium falciparum - pathogenicity Proteins Viral infections West Nile virus |
title | Inflammation and Elevated Osteopontin in Plasma and CSF in Cerebral Malaria Compared to Plasmodium -Negative Neurological Infections |
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