Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). The study includes 213 ICU patients with clinical criteria of sepsi...

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Published in:BMC infectious diseases 2017-08, Vol.17 (1), p.554-554, Article 554
Main Authors: Hamed, Sonja, Behnes, Michael, Pauly, Dominic, Lepiorz, Dominic, Barre, Max, Becher, Tobias, Lang, Siegfried, Akin, Ibrahim, Borggrefe, Martin, Bertsch, Thomas, Hoffmann, Ursula
Format: Article
Language:English
Subjects:
Acute phase proteins
Adult
Aged
Aged, 80 and over
APACHE
Biomarkers
Biomarkers - blood
Blood
Body temperature
C-reactive protein
C-Reactive Protein - analysis
Calcitonin - blood
Care and treatment
Cytokines
Diagnosis
Diagnostic systems
Emergency medical care
Family medical history
Family physicians
Female
Heart rate
Hospitals
Humans
ICU
Infections
Infectious diseases
Inflammation
Intensive care
Intensive Care Units
Interleukin 6
Interleukin-6 - blood
Interleukins
Lactic acid
Male
Medicine
Middle Aged
Monocytes
Mortality
Patients
Pentraxin-3
Pentraxins
Plasma levels
Procalcitonin
Prognosis
Sepsis
Sepsis - blood
Sepsis - therapy
Sepsis-3
Septic shock
Serum Amyloid P-Component - analysis
Shock, Septic - blood
Shock, Septic - therapy
Studies
Toll-like receptors
Tumor necrosis factor
Tumor necrosis factor-TNF
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cited_by cdi_FETCH-LOGICAL-c628t-98b2b670b7bde10f49d20694c1b783e8620d85ac93140ddb69734e45d1f943df3
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container_title BMC infectious diseases
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creator Hamed, Sonja
Behnes, Michael
Pauly, Dominic
Lepiorz, Dominic
Barre, Max
Becher, Tobias
Lang, Siegfried
Akin, Ibrahim
Borggrefe, Martin
Bertsch, Thomas
Hoffmann, Ursula
description Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73-0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. NCT01535534 . Registered 14.02.2012.
doi_str_mv 10.1186/s12879-017-2606-3
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This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73-0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. NCT01535534 . 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This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73-0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. NCT01535534 . 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Behnes, Michael ; Pauly, Dominic ; Lepiorz, Dominic ; Barre, Max ; Becher, Tobias ; Lang, Siegfried ; Akin, Ibrahim ; Borggrefe, Martin ; Bertsch, Thomas ; Hoffmann, Ursula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-98b2b670b7bde10f49d20694c1b783e8620d85ac93140ddb69734e45d1f943df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute phase proteins</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>APACHE</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Body temperature</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Calcitonin - blood</topic><topic>Care and treatment</topic><topic>Cytokines</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Emergency medical care</topic><topic>Family medical history</topic><topic>Family physicians</topic><topic>Female</topic><topic>Heart rate</topic><topic>Hospitals</topic><topic>Humans</topic><topic>ICU</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Intensive care</topic><topic>Intensive Care Units</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Interleukins</topic><topic>Lactic acid</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Mortality</topic><topic>Patients</topic><topic>Pentraxin-3</topic><topic>Pentraxins</topic><topic>Plasma levels</topic><topic>Procalcitonin</topic><topic>Prognosis</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - therapy</topic><topic>Sepsis-3</topic><topic>Septic shock</topic><topic>Serum Amyloid P-Component - analysis</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - therapy</topic><topic>Studies</topic><topic>Toll-like receptors</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamed, Sonja</creatorcontrib><creatorcontrib>Behnes, Michael</creatorcontrib><creatorcontrib>Pauly, Dominic</creatorcontrib><creatorcontrib>Lepiorz, Dominic</creatorcontrib><creatorcontrib>Barre, Max</creatorcontrib><creatorcontrib>Becher, Tobias</creatorcontrib><creatorcontrib>Lang, Siegfried</creatorcontrib><creatorcontrib>Akin, Ibrahim</creatorcontrib><creatorcontrib>Borggrefe, Martin</creatorcontrib><creatorcontrib>Bertsch, Thomas</creatorcontrib><creatorcontrib>Hoffmann, Ursula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; 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1471-2334
language eng
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subjects Acute phase proteins
Adult
Aged
Aged, 80 and over
APACHE
Biomarkers
Biomarkers - blood
Blood
Body temperature
C-reactive protein
C-Reactive Protein - analysis
Calcitonin - blood
Care and treatment
Cytokines
Diagnosis
Diagnostic systems
Emergency medical care
Family medical history
Family physicians
Female
Heart rate
Hospitals
Humans
ICU
Infections
Infectious diseases
Inflammation
Intensive care
Intensive Care Units
Interleukin 6
Interleukin-6 - blood
Interleukins
Lactic acid
Male
Medicine
Middle Aged
Monocytes
Mortality
Patients
Pentraxin-3
Pentraxins
Plasma levels
Procalcitonin
Prognosis
Sepsis
Sepsis - blood
Sepsis - therapy
Sepsis-3
Septic shock
Serum Amyloid P-Component - analysis
Shock, Septic - blood
Shock, Septic - therapy
Studies
Toll-like receptors
Tumor necrosis factor
Tumor necrosis factor-TNF
title Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
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