CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expressi...

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Bibliographic Details
Published in:Biological research 2014-09, Vol.47 (1), p.43-43, Article 43
Main Authors: García-Labastida, Laura, Garza-Guajardo, Raquel, Barboza-Quintana, Oralia, Rodríguez-Sanchez, Irám Pablo, Ancer-Rodríguez, Jesús, Flores-Gutierrez, Juan Pablo, Gómez-Macías, Gabriela Sofía
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - chemistry
Adenocarcinoma, Mucinous - pathology
Adult
Aged
Aged, 80 and over
Antigens, Differentiation - analysis
beta Catenin - analysis
Biological markers
BIOLOGY
Biomarkers, Tumor - analysis
Breast cancer
Breast mucinous carcinoma
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
CDX2 Transcription Factor
Diagnosis
Female
Genetic aspects
Homeodomain Proteins - analysis
Humans
Immunohistochemistry
Inmunohistochemical
Intestinal differentiation
Intestinal Mucosa - chemistry
Middle Aged
Mucin-2 - analysis
Retrospective Studies
Trans-Activators - analysis
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Summary:Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
ISSN:0717-6287
0716-9760
0717-6287
DOI:10.1186/0717-6287-47-43