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Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location
•This is the first study on LODDS and ENE together. The current study showed that LODDS and ENE are liable prognostic parameters of CRC or CC.•ENE is an independent influencing factor on the prognosis of both CRC and CC, and the prognostic impact of ENE was observed in both CRC and CC.•The frequency...
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| Published in: | Translational oncology 2021-11, Vol.14 (11), p.101190-101190, Article 101190 |
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| creator | Li, Tengfei Yang, Yan Wu, Weidong Fu, Zhongmao Cheng, Feichi Qiu, Jiahui Li, Qi Zhang, Kundong Luo, Zai Qiu, Zhengjun Huang, Chen |
| description | •This is the first study on LODDS and ENE together. The current study showed that LODDS and ENE are liable prognostic parameters of CRC or CC.•ENE is an independent influencing factor on the prognosis of both CRC and CC, and the prognostic impact of ENE was observed in both CRC and CC.•The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum.
Extranodal extension (ENE) and log odds of positive lymph nodes (LODDS) are associated with the aggressiveness of both colon and rectal cancers. The current study evaluated the clinicopathological significance and the prognostic impact of ENE and LODDS in the colon and rectal patients independently.
The clinical and histological records of 389 colorectal cancer (CRC) patients who underwent curative surgery were reviewed.
For the ENE system, 244 patients were in the ENE1 group and 145 in the ENE2 system. Compared with the ENE1 system, the patients included in the ENE2 system were prone to nerve invasion (P |
| doi_str_mv | 10.1016/j.tranon.2021.101190 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_db7b90df5cae469290cbba75d4be6d6e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1936523321001820</els_id><doaj_id>oai_doaj_org_article_db7b90df5cae469290cbba75d4be6d6e</doaj_id><sourcerecordid>2562521409</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-96eafe088e9a32aa89431eff73af042f1f79e95d1b55fa302bdac4cebdaf77ed3</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiMEoh_wDzj4yCVbfyTO-oKE2gUqrSgScLYm9njrlWMHO7tS_z3ZpgJ64TCa0czosed9q-odoytGmbzar6YMMcUVp5ydWkzRF9U5U0LWLRfi5T_1WXVRyp5SyRTnr6sz0TRUKCrPK_ctp11MZfKG-GEM3sDkUywkObL5uiEQLdne3dx8Jz6SjOFxSqZEwsMw3pOYLNZjKn7yRyQmhZTRTBCIgWgwk5AW3pvqlYNQ8O1Tvqx-ftr8uP5Sb-8-315_3NampXKqlURwSNdrVCA4wFo1gqFznQBHG-6Y6xSq1rK-bR0IynsLpjE4J9d1aMVldbtwbYK9HrMfID_oBF4_NlLeacjzrQG17bteUetaA9hIxRU1fQ9da5sepZU4sz4srPHQD2gNxlnw8Az6fBL9vd6lo14L2c0xA94_AXL6dcAy6cEXgyFAxHQomreSt5w1VM2rzbJqciolo_vzDKP6ZLfe68VufbJbL3b__SLOmh49Zl2Mx1l5608-zEf7_wN-AyhCt3s</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2562521409</pqid></control><display><type>article</type><title>Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location</title><source>PubMed (Medline)</source><source>ScienceDirect®</source><creator>Li, Tengfei ; Yang, Yan ; Wu, Weidong ; Fu, Zhongmao ; Cheng, Feichi ; Qiu, Jiahui ; Li, Qi ; Zhang, Kundong ; Luo, Zai ; Qiu, Zhengjun ; Huang, Chen</creator><creatorcontrib>Li, Tengfei ; Yang, Yan ; Wu, Weidong ; Fu, Zhongmao ; Cheng, Feichi ; Qiu, Jiahui ; Li, Qi ; Zhang, Kundong ; Luo, Zai ; Qiu, Zhengjun ; Huang, Chen</creatorcontrib><description><![CDATA[•This is the first study on LODDS and ENE together. The current study showed that LODDS and ENE are liable prognostic parameters of CRC or CC.•ENE is an independent influencing factor on the prognosis of both CRC and CC, and the prognostic impact of ENE was observed in both CRC and CC.•The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum.
Extranodal extension (ENE) and log odds of positive lymph nodes (LODDS) are associated with the aggressiveness of both colon and rectal cancers. The current study evaluated the clinicopathological significance and the prognostic impact of ENE and LODDS in the colon and rectal patients independently.
The clinical and histological records of 389 colorectal cancer (CRC) patients who underwent curative surgery were reviewed.
For the ENE system, 244 patients were in the ENE1 group and 145 in the ENE2 system. Compared with the ENE1 system, the patients included in the ENE2 system were prone to nerve invasion (P < 0.001) and vessel invasion (P < 0.001) with higher TNM (P = 0.009), higher T category (P = 0.003), higher N category (P < 0.001), advanced differentiation (P = 0.013), more number of positive lymph nodes (NPLN) (P < 0.001), more lymph node ratio (LNR) (P < 0.001), and a higher value of LODDS (P < 0.001). ENE was more frequent in patients with left and rectal than right cancer. For the LODDS system, 280 patients were in the LODDS1 group, and 109 in the LODDS2 group. Compared to the LODDS1 group, the patients included in the LODDS2 group were more prone to nerve invasion (P = 0.0351) and vessel invasion (P < 0.001) with a higher rate of N2 stage, less NDLN (P < 0.001), more NPLN (P < 0.001), more LNR (P < 0.001), and a higher value of ENE (P < 0.001). Based on the results in the univariable analysis, the N, NPLN, LNR, LODDS, and ENE were separately incorporated into five different Cox regression models combined with the same confounders. The multivariable Cox regression analysis demonstrated that all the five staging systems were independent prognostic factors for overall survival.
The current study confirmed that the LODDS stage is an independent influence on the prognosis of both CRC and CC patients. ENE is an independent influencing factor on the prognosis of both CRC and CC patients, and the prognostic impact of extracapsular lymph node was observed in both CRC and CC. The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum. Therefore, combining ENE and LODDS into the current TNM system to compensate for the inadequacy of pN staging needs further investigation.]]></description><identifier>ISSN: 1936-5233</identifier><identifier>EISSN: 1936-5233</identifier><identifier>DOI: 10.1016/j.tranon.2021.101190</identifier><identifier>PMID: 34403906</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Colorectal cancer ; Extranodal extension ; Log odds of positive lymph nodes ; Lymph node-positive ; Original Research ; Tumor location</subject><ispartof>Translational oncology, 2021-11, Vol.14 (11), p.101190-101190, Article 101190</ispartof><rights>2021</rights><rights>2021 Published by Elsevier Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-96eafe088e9a32aa89431eff73af042f1f79e95d1b55fa302bdac4cebdaf77ed3</citedby><cites>FETCH-LOGICAL-c506t-96eafe088e9a32aa89431eff73af042f1f79e95d1b55fa302bdac4cebdaf77ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367836/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1936523321001820$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3548,27923,27924,45779,53790,53792</link.rule.ids></links><search><creatorcontrib>Li, Tengfei</creatorcontrib><creatorcontrib>Yang, Yan</creatorcontrib><creatorcontrib>Wu, Weidong</creatorcontrib><creatorcontrib>Fu, Zhongmao</creatorcontrib><creatorcontrib>Cheng, Feichi</creatorcontrib><creatorcontrib>Qiu, Jiahui</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Zhang, Kundong</creatorcontrib><creatorcontrib>Luo, Zai</creatorcontrib><creatorcontrib>Qiu, Zhengjun</creatorcontrib><creatorcontrib>Huang, Chen</creatorcontrib><title>Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location</title><title>Translational oncology</title><description><![CDATA[•This is the first study on LODDS and ENE together. The current study showed that LODDS and ENE are liable prognostic parameters of CRC or CC.•ENE is an independent influencing factor on the prognosis of both CRC and CC, and the prognostic impact of ENE was observed in both CRC and CC.•The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum.
Extranodal extension (ENE) and log odds of positive lymph nodes (LODDS) are associated with the aggressiveness of both colon and rectal cancers. The current study evaluated the clinicopathological significance and the prognostic impact of ENE and LODDS in the colon and rectal patients independently.
The clinical and histological records of 389 colorectal cancer (CRC) patients who underwent curative surgery were reviewed.
For the ENE system, 244 patients were in the ENE1 group and 145 in the ENE2 system. Compared with the ENE1 system, the patients included in the ENE2 system were prone to nerve invasion (P < 0.001) and vessel invasion (P < 0.001) with higher TNM (P = 0.009), higher T category (P = 0.003), higher N category (P < 0.001), advanced differentiation (P = 0.013), more number of positive lymph nodes (NPLN) (P < 0.001), more lymph node ratio (LNR) (P < 0.001), and a higher value of LODDS (P < 0.001). ENE was more frequent in patients with left and rectal than right cancer. For the LODDS system, 280 patients were in the LODDS1 group, and 109 in the LODDS2 group. Compared to the LODDS1 group, the patients included in the LODDS2 group were more prone to nerve invasion (P = 0.0351) and vessel invasion (P < 0.001) with a higher rate of N2 stage, less NDLN (P < 0.001), more NPLN (P < 0.001), more LNR (P < 0.001), and a higher value of ENE (P < 0.001). Based on the results in the univariable analysis, the N, NPLN, LNR, LODDS, and ENE were separately incorporated into five different Cox regression models combined with the same confounders. The multivariable Cox regression analysis demonstrated that all the five staging systems were independent prognostic factors for overall survival.
The current study confirmed that the LODDS stage is an independent influence on the prognosis of both CRC and CC patients. ENE is an independent influencing factor on the prognosis of both CRC and CC patients, and the prognostic impact of extracapsular lymph node was observed in both CRC and CC. The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum. Therefore, combining ENE and LODDS into the current TNM system to compensate for the inadequacy of pN staging needs further investigation.]]></description><subject>Colorectal cancer</subject><subject>Extranodal extension</subject><subject>Log odds of positive lymph nodes</subject><subject>Lymph node-positive</subject><subject>Original Research</subject><subject>Tumor location</subject><issn>1936-5233</issn><issn>1936-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kU1v1DAQhiMEoh_wDzj4yCVbfyTO-oKE2gUqrSgScLYm9njrlWMHO7tS_z3ZpgJ64TCa0czosed9q-odoytGmbzar6YMMcUVp5ydWkzRF9U5U0LWLRfi5T_1WXVRyp5SyRTnr6sz0TRUKCrPK_ctp11MZfKG-GEM3sDkUywkObL5uiEQLdne3dx8Jz6SjOFxSqZEwsMw3pOYLNZjKn7yRyQmhZTRTBCIgWgwk5AW3pvqlYNQ8O1Tvqx-ftr8uP5Sb-8-315_3NampXKqlURwSNdrVCA4wFo1gqFznQBHG-6Y6xSq1rK-bR0IynsLpjE4J9d1aMVldbtwbYK9HrMfID_oBF4_NlLeacjzrQG17bteUetaA9hIxRU1fQ9da5sepZU4sz4srPHQD2gNxlnw8Az6fBL9vd6lo14L2c0xA94_AXL6dcAy6cEXgyFAxHQomreSt5w1VM2rzbJqciolo_vzDKP6ZLfe68VufbJbL3b__SLOmh49Zl2Mx1l5608-zEf7_wN-AyhCt3s</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Li, Tengfei</creator><creator>Yang, Yan</creator><creator>Wu, Weidong</creator><creator>Fu, Zhongmao</creator><creator>Cheng, Feichi</creator><creator>Qiu, Jiahui</creator><creator>Li, Qi</creator><creator>Zhang, Kundong</creator><creator>Luo, Zai</creator><creator>Qiu, Zhengjun</creator><creator>Huang, Chen</creator><general>Elsevier Inc</general><general>Neoplasia Press</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211101</creationdate><title>Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location</title><author>Li, Tengfei ; Yang, Yan ; Wu, Weidong ; Fu, Zhongmao ; Cheng, Feichi ; Qiu, Jiahui ; Li, Qi ; Zhang, Kundong ; Luo, Zai ; Qiu, Zhengjun ; Huang, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-96eafe088e9a32aa89431eff73af042f1f79e95d1b55fa302bdac4cebdaf77ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Colorectal cancer</topic><topic>Extranodal extension</topic><topic>Log odds of positive lymph nodes</topic><topic>Lymph node-positive</topic><topic>Original Research</topic><topic>Tumor location</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Tengfei</creatorcontrib><creatorcontrib>Yang, Yan</creatorcontrib><creatorcontrib>Wu, Weidong</creatorcontrib><creatorcontrib>Fu, Zhongmao</creatorcontrib><creatorcontrib>Cheng, Feichi</creatorcontrib><creatorcontrib>Qiu, Jiahui</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Zhang, Kundong</creatorcontrib><creatorcontrib>Luo, Zai</creatorcontrib><creatorcontrib>Qiu, Zhengjun</creatorcontrib><creatorcontrib>Huang, Chen</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Tengfei</au><au>Yang, Yan</au><au>Wu, Weidong</au><au>Fu, Zhongmao</au><au>Cheng, Feichi</au><au>Qiu, Jiahui</au><au>Li, Qi</au><au>Zhang, Kundong</au><au>Luo, Zai</au><au>Qiu, Zhengjun</au><au>Huang, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location</atitle><jtitle>Translational oncology</jtitle><date>2021-11-01</date><risdate>2021</risdate><volume>14</volume><issue>11</issue><spage>101190</spage><epage>101190</epage><pages>101190-101190</pages><artnum>101190</artnum><issn>1936-5233</issn><eissn>1936-5233</eissn><abstract><![CDATA[•This is the first study on LODDS and ENE together. The current study showed that LODDS and ENE are liable prognostic parameters of CRC or CC.•ENE is an independent influencing factor on the prognosis of both CRC and CC, and the prognostic impact of ENE was observed in both CRC and CC.•The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum.
Extranodal extension (ENE) and log odds of positive lymph nodes (LODDS) are associated with the aggressiveness of both colon and rectal cancers. The current study evaluated the clinicopathological significance and the prognostic impact of ENE and LODDS in the colon and rectal patients independently.
The clinical and histological records of 389 colorectal cancer (CRC) patients who underwent curative surgery were reviewed.
For the ENE system, 244 patients were in the ENE1 group and 145 in the ENE2 system. Compared with the ENE1 system, the patients included in the ENE2 system were prone to nerve invasion (P < 0.001) and vessel invasion (P < 0.001) with higher TNM (P = 0.009), higher T category (P = 0.003), higher N category (P < 0.001), advanced differentiation (P = 0.013), more number of positive lymph nodes (NPLN) (P < 0.001), more lymph node ratio (LNR) (P < 0.001), and a higher value of LODDS (P < 0.001). ENE was more frequent in patients with left and rectal than right cancer. For the LODDS system, 280 patients were in the LODDS1 group, and 109 in the LODDS2 group. Compared to the LODDS1 group, the patients included in the LODDS2 group were more prone to nerve invasion (P = 0.0351) and vessel invasion (P < 0.001) with a higher rate of N2 stage, less NDLN (P < 0.001), more NPLN (P < 0.001), more LNR (P < 0.001), and a higher value of ENE (P < 0.001). Based on the results in the univariable analysis, the N, NPLN, LNR, LODDS, and ENE were separately incorporated into five different Cox regression models combined with the same confounders. The multivariable Cox regression analysis demonstrated that all the five staging systems were independent prognostic factors for overall survival.
The current study confirmed that the LODDS stage is an independent influence on the prognosis of both CRC and CC patients. ENE is an independent influencing factor on the prognosis of both CRC and CC patients, and the prognostic impact of extracapsular lymph node was observed in both CRC and CC. The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum. Therefore, combining ENE and LODDS into the current TNM system to compensate for the inadequacy of pN staging needs further investigation.]]></abstract><pub>Elsevier Inc</pub><pmid>34403906</pmid><doi>10.1016/j.tranon.2021.101190</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Colorectal cancer Extranodal extension Log odds of positive lymph nodes Lymph node-positive Original Research Tumor location |
| title | Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location |
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