Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis

Teratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of teratomas may provide a better understanding of their stepwise differentiation processes and molecular bases, which could prove useful for the development of ti...

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Bibliographic Details
Published in:Journal of ovarian research 2024-06, Vol.17 (1), p.129-12, Article 129
Main Authors: Wang, Wen-Chung, Hou, Tai-Cheng, Kuo, Chen-Yun, Lai, Yen-Chein
Format: Article
Language:English
Subjects:
Adult
Analysis
Array comparative genomic hybridization
Chondrogenesis
Chondrogenesis - genetics
Comparative Genomic Hybridization
Ethylenediaminetetraacetic acid
Female
Genes
Genetics
Homeodomain Proteins - genetics
Humans
Instrument industry
Mature cystic teratoma of the ovary
Middle Aged
Neoplasm Proteins
Osteogenesis
Osteogenesis - genetics
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Teratoma
Teratoma - genetics
Teratoma - pathology
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Teratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of teratomas may provide a better understanding of their stepwise differentiation processes and molecular bases, which could prove useful for the development of tissue-engineering technologies. In the present study, we analyzed the copy number aberrations of nine ovarian mature cystic teratomas using array comparative genomic hybridization in an attempt to reveal their genomic aberrations. The many chromosomal aberrations observed on array comparative genomic hybridization analysis reveal the complex genetics of this tumor. Amplifications and deletions of large DNA fragments were observed in some samples, while amplifications of EVX2 and HOXD9-HOXD13 on 2q31.1, NDUFV1 on 11q13.2, and RPL10, SNORA70, DNASE1L1, TAZ, ATP6AP1, and GDI1 on Xq28 were found in all nine mature cystic teratomas. Our results indicated that amplifications of these genes may play an important etiological role in teratoma formation. Moreover, amplifications of EVX2 and HOXD9-HOXD13 on 2q31.1, found on array comparative genomic hybridization, may help to explain the characteristics of teratomas in chondrogenesis and osteogenesis.
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-024-01458-5