Desenvolvimento de um método para a determinação de tioconazol associado a nanocápsulas poliméricas por cromatografia líquida

The aim of this work was to develop and validate an analytical method for the quantification of tioconazole in polymeric nanocapsule suspensions by high performance liquid chromatography with UV detection. The analysis was performed with a mobile phase composed of methanol:water (80:20) and 0.18% am...

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Published in:Química Nova 2014-07, Vol.37 (6), p.996-999
Main Authors: Andréia P. G. Härter, Mariana H. Motta, Júlia G. de Barros, Roseane F. Ribeiro, Andréa I. H. Adams, Scheila R. Schaffazick, Cristiane de B. da Silva
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Language:English
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polymeric nanocapsules
tioconazole
validation
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container_end_page 999
container_issue 6
container_start_page 996
container_title Química Nova
container_volume 37
creator Andréia P. G. Härter
Mariana H. Motta
Júlia G. de Barros
Roseane F. Ribeiro
Andréa I. H. Adams
Scheila R. Schaffazick
Cristiane de B. da Silva
description The aim of this work was to develop and validate an analytical method for the quantification of tioconazole in polymeric nanocapsule suspensions by high performance liquid chromatography with UV detection. The analysis was performed with a mobile phase composed of methanol:water (80:20) and 0.18% ammonium hydroxide; RP-18 column and UV detection at 219 nm. The method proved to be linear in the concentration range of 5-50 µg mL-1 (r = 0.9999), specific, precise (repeatability RSD = 1.42%, intermediate precision RSD = 1.17%), accurate (98 - 102%) and robust (RSD < 2.0%). In conclusion, a simple and rapid method was validated proving suitable for quantification of tioconazole in polymeric nanocapsules.
doi_str_mv 10.5935/0100-4042.20140153
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subjects polymeric nanocapsules
tioconazole
validation
title Desenvolvimento de um método para a determinação de tioconazol associado a nanocápsulas poliméricas por cromatografia líquida
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