The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells

Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key...

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Bibliographic Details
Published in:Analytical cellular pathology (Amsterdam) 2020, Vol.2020 (2020), p.1-9
Main Authors: Tashjian, Hagop, Jaafar, Leila, El Atat, Oula, Al-Koussa, Houssam, El-Sibai, Mirvat
Format: Article
Language:English
Subjects:
Animals
Brain Neoplasms - enzymology
Brain Neoplasms - pathology
Brain tumors
Cell Movement - physiology
G proteins
Glioblastoma - enzymology
Glioblastoma - pathology
Glioblastoma multiforme
Humans
Muscle proteins
Neoplasm Invasiveness - pathology
Review
rho GTP-Binding Proteins - metabolism
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Summary:Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells. In this review, we describe the role played by the Rho family of GTPases in the regulation of the invasion and migration of glioblastoma cells. Specifically, we focus on the role played by RhoA, Rac1, RhoG, and Cdc42 in cell migration through rearrangement of actin cytoskeleton, cell adhesion, and invasion. Finally, we highlight the importance of potentially targeting Rho GTPases in the treatment of glioblastoma.
ISSN:2210-7177
2210-7185
DOI:10.1155/2020/9274016