Chronic fluoxetine treatment induces lipid accumulation but does not alter the expression of Pref-1 in rat adipose tissue

This study aims to investigate the effects of chronic fluoxetine (FLX) treatment on preadipocyte factor-1 (Pref-1) expression in subcutaneous, visceral and brown adipose tissues, and on the size of vacuoles in a dipocytes obtained from the perirenal regions in rats. Twenty-eight Wistar rats were tre...

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Bibliographic Details
Published in:Acta pharmaceutica (Zagreb, Croatia) Croatia), 2018-03, Vol.68 (1), p.109-115
Main Authors: Bába, László-István, Gáll, Zsolt, Bíró, István Lóránt, Mezei, Tibor, Kun, Imre Zoltán, Kolcsár, Melinda
Format: Article
Language:English
Subjects:
Adipose tissue
Animal tissues
Animals
Fluoxetine
Lipids
preadipocyte factor-1
Rats
vacuole size
Vacuoles
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Summary:This study aims to investigate the effects of chronic fluoxetine (FLX) treatment on preadipocyte factor-1 (Pref-1) expression in subcutaneous, visceral and brown adipose tissues, and on the size of vacuoles in a dipocytes obtained from the perirenal regions in rats. Twenty-eight Wistar rats were treated with FLX at two different doses and fourteen animals received vehicle. After 40 days of treatment, the subcutaneous, perirenal and interscapular adipose tissues were collected. Pref-1 expression was examined using an immunohistochemical method and the vacuolar area was measured in stained sections. In the low dose FLX group, the size of vacuoles increased both in male and female animals. The high dose of FLX also induced a significant increase of vacuole size, but only in male animals. Neither of the two doses of FLX has significantly affected the Pref-1 expression in any type of adipose tissue.
ISSN:1846-9558
1330-0075
1846-9558
DOI:10.2478/acph-2018-0009