Oxidative Phosphorylation Dysfunction Modifies the Cell Secretome

Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphoryl...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-05, Vol.21 (9), p.3374
Main Authors: Garrido-Pérez, Nuria, Vela-Sebastián, Ana, López-Gallardo, Ester, Emperador, Sonia, Iglesias, Eldris, Meade, Patricia, Jiménez-Mallebrera, Cecilia, Montoya, Julio, Bayona-Bafaluy, M Pilar, Ruiz-Pesini, Eduardo
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Adipocytes
Biomarkers
Biomarkers - metabolism
Clinical trials
Cytochrome
Deoxyribonucleic acid
Diagnostic systems
Disease
DNA
DNA, Mitochondrial - genetics
fibroblast growth factor 21
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - metabolism
Genetic testing
Genetic variability
Genomes
Growth Differentiation Factor 15 - genetics
Growth Differentiation Factor 15 - metabolism
Humans
Interleukin-6 - metabolism
Kinases
Metabolism
Mitochondria
mitochondrial diseases
Mitochondrial Diseases - genetics
Mitochondrial Diseases - metabolism
Mitochondrial DNA
Mutation
Oxidative Phosphorylation
oxidative phosphorylation system
Phosphorylation
Physiology
Proteins
Review
Roles
Secretome
Secretory Pathway - drug effects
Secretory Pathway - genetics
Signal transduction
Stem cells
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell's secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21093374