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Oxidative Phosphorylation Dysfunction Modifies the Cell Secretome
Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphoryl...
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| Published in: | International journal of molecular sciences 2020-05, Vol.21 (9), p.3374 |
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| container_issue | 9 |
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| container_title | International journal of molecular sciences |
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| creator | Garrido-Pérez, Nuria Vela-Sebastián, Ana López-Gallardo, Ester Emperador, Sonia Iglesias, Eldris Meade, Patricia Jiménez-Mallebrera, Cecilia Montoya, Julio Bayona-Bafaluy, M Pilar Ruiz-Pesini, Eduardo |
| description | Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell's secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials. |
| doi_str_mv | 10.3390/ijms21093374 |
| format | article |
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Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell's secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. 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| subjects | Adenosine triphosphate Adipocytes Biomarkers Biomarkers - metabolism Clinical trials Cytochrome Deoxyribonucleic acid Diagnostic systems Disease DNA DNA, Mitochondrial - genetics fibroblast growth factor 21 Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Genetic testing Genetic variability Genomes Growth Differentiation Factor 15 - genetics Growth Differentiation Factor 15 - metabolism Humans Interleukin-6 - metabolism Kinases Metabolism Mitochondria mitochondrial diseases Mitochondrial Diseases - genetics Mitochondrial Diseases - metabolism Mitochondrial DNA Mutation Oxidative Phosphorylation oxidative phosphorylation system Phosphorylation Physiology Proteins Review Roles Secretome Secretory Pathway - drug effects Secretory Pathway - genetics Signal transduction Stem cells Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism |
| title | Oxidative Phosphorylation Dysfunction Modifies the Cell Secretome |
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