Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, act...

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Published in:Anais da Academia Brasileira de Ciências 2016-10, Vol.88 (4), p.2349-2356
Main Authors: Costa-Silva, Danylo R, Barros-Oliveira, Maria DA Conceição, Borges, Rafael S, Tavares, Cléciton B, Borges, Umbelina S, Alves-Ribeiro, Francisco A, Silva, Vladimir C, Silva, Benedito B DA
Format: Article
Language:English
Subjects:
Alleles
Breast cancer
Breast Neoplasms - genetics
Cell Proliferation
Dinucleotide Repeats
Female
Gene Expression
Humans
IGF-1
IGF-1 gene polymorphism
Insulin-Like Growth Factor I - genetics
MULTIDISCIPLINARY SCIENCES
Polymorphism, Genetic
Risk Factors
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Summary:Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765201620160169