Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

• Published in: Anais da Academia Brasileira de Ciências 2016-10, Vol.88 (4), p.2349-2356
• Main Authors: Costa-Silva, Danylo R, Barros-Oliveira, Maria DA Conceição, Borges, Rafael S, Tavares, Cléciton B, Borges, Umbelina S, Alves-Ribeiro, Francisco A, Silva, Vladimir C, Silva, Benedito B DA
• Format: Article
• Language: English
• Subjects: Alleles; Breast cancer; Breast Neoplasms - genetics; Cell Proliferation; Dinucleotide Repeats; Female; Gene Expression; Humans; IGF-1; IGF-1 gene polymorphism; Insulin-Like Growth Factor I - genetics; MULTIDISCIPLINARY SCIENCES; Polymorphism, Genetic; Risk Factors
• ISSN: 0001-3765; 1678-2690; 1678-2690
• DOI: 10.1590/0001-3765201620160169

Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.