A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury

• Published in: Critical care (London, England) England), 2023-06, Vol.27 (1), p.239-239, Article 239
• Main Authors: Barbeta, Enric, Arrieta, Marta, Motos, Ana, Bobi, Joaquim, Yang, Hua, Yang, Minlan, Tanzella, Giacomo, Di Ginnatale, Pierluigi, Nogas, Stefano, Vargas, Carmen Rosa, Cabrera, Roberto, Battaglini, Denise, Meli, Andrea, Kiarostami, Kasra, Vázquez, Nil, Fernández-Barat, Laia, Rigol, Montserrat, Mellado-Artigas, Ricard, Frigola, Gerard, Camprubí-Rimblas, Marta, Ferrer, Pau, Martinez, Daniel, Artigas, Antonio, Ferrando, Carlos, Ferrer, Miquel, Torres, Antoni
• Format: Article
• Language: English
• Subjects: Acute respiratory distress syndrome; Animals; ARDS; Bronchoscopy; Care and treatment; Complications and side effects; Critical care; Development and progression; Double hit; Drug resistance in microorganisms; Experiments; Hemodynamics; Injurious mechanical ventilation; Mechanics; Patient outcomes; Pneumonia; Porcine model; Prevention; Respiratory system; Ventilation; Ventilator-associated pneumonia; Ventilator-induced lung injury; Ventilators
• ISSN: 1364-8535; 1466-609X; 1364-8535; 1366-609X
• DOI: 10.1186/s13054-023-04512-8

Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia-the most common risk factor in humans-and analyze the additional effect of ventilator-induced lung injury (VILI). Bronchoscopy-guided instillation of a multidrug-resistant Pseudomonas aeruginosa strain was performed in ten healthy pigs. In six animals (pneumonia-with-VILI group), pulmonary damage was further increased by VILI applied 3 h before instillation and until ARDS was diagnosed by PaO /FiO