Mannose receptor may be involved in small ruminant lentivirus pathogenesis

• Published in: Veterinary research (Paris) 2012-05, Vol.43 (1), p.43-43, Article 43
• Main Authors: Crespo, Helena, Jauregui, Paula, Glaria, Idoia, Sanjosé, Leticia, Polledo, Laura, García-Marín, Juan F, Luján, Lluís, de Andrés, Damián, Amorena, Beatriz, Reina, Ramsés
• Format: Article
• Language: English
• Subjects: Analysis; Animals; Arthritis; Arthritis - genetics; Arthritis - veterinary; Arthritis - virology; Bacterial pneumonia; Encephalitis - genetics; Encephalitis - veterinary; Encephalitis - virology; Female; Gene expression; Gene Expression Regulation; Genetic aspects; Health aspects; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Lentivirus; Lentivirus Infections - genetics; Lentivirus Infections - veterinary; Lentivirus Infections - virology; Lentiviruses, Ovine-Caprine - isolation & purification; Male; Mannose receptors; Mannose-Binding Lectins - genetics; Mannose-Binding Lectins - metabolism; Monosaccharides; Nervous system diseases; Organ Specificity; Physiological aspects; Pneumonia; Pneumonia - genetics; Pneumonia - veterinary; Pneumonia - virology; Proviruses - isolation & purification; Real-Time Polymerase Chain Reaction - veterinary; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Sheep; Sheep Diseases - genetics; Sheep Diseases - virology; Short Report; Spain; Sugars; Viral Load - veterinary
• ISSN: 1297-9716; 0928-4249; 1297-9716
• DOI: 10.1186/1297-9716-43-43

Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.