Real-time contrast-enhanced ultrasound-guided percutaneous biopsy in the diagnosis of ovarian metastasis of gallbladder carcinoma: a case report

Multiple-organ primary tumors can invade the ovary through lymphatic and hematogenous routes, presenting as ovarian Krukenberg tumors, but these rarely originate from the gallbladder. Krukenberg tumors can present similar to primary ovarian tumors; however, their treatments are completely different....

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Bibliographic Details
Published in:Journal of ovarian research 2023-07, Vol.16 (1), p.133-133, Article 133
Main Authors: Wang, Jing, Liu, Yanjun, Sang, Liang, Wan, Weina
Format: Article
Language:English
Subjects:
Abdomen
Antigens
Biomarkers
Biopsy
Blood vessels
Cancer
Cancer therapies
Carcinoma
Case Report
Case reports
Chemotherapy
Cisplatin
Contrast-enhanced ultrasound (CEUS)-guided
Cytokeratin
Development and progression
Diabetes
Diagnosis
Distension
Gallbladder cancer
Gallbladder carcinoma
Gemcitabine
Health aspects
Hypertension
Krukenberg tumor
Malignancy
Medical prognosis
Metastases
Metastasis
Omentum
Ovarian cancer
Ovarian carcinoma
Patients
Percutaneous biopsy
Surgery
Tomography
Tumors
Ultrasonic imaging
Ultrasound
Weight loss
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Summary:Multiple-organ primary tumors can invade the ovary through lymphatic and hematogenous routes, presenting as ovarian Krukenberg tumors, but these rarely originate from the gallbladder. Krukenberg tumors can present similar to primary ovarian tumors; however, their treatments are completely different. A 62-year-old Chinese woman presented with abdominal distension for six months and weight loss of five kilograms for two months. Based on multiple imaging examinations, the patient was preliminarily diagnosed with a malignant tumor of unknown origin with multiple metastases (omentum). To identify the origin of the malignancy, the patient underwent real-time contrast-enhanced ultrasound-guided percutaneous biopsy. The results revealed a perihepatic hypoechoic lesion and right adnexal mass that were both metastatic adenocarcinomas from the gallbladder. The patient initially received chemotherapy with gemcitabine and cisplatin instead of surgery. However, the tumor increased in size on re-examination after two cycles, so the treatment was shifted to a combination regimen with durvalumab for six cycles. The treatment proceeded smoothly, with no recurrence or obvious progression of the cancer during follow-up. Differentiating between primary and metastatic ovarian tumors is important. Early diagnosis and effective treatment options are essential for patient survival. CEUS-guided percutaneous biopsy is a valuable procedure for patients with multiple metastases who cannot tolerate surgery.
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-023-01198-y