Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions

Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times,...

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Bibliographic Details
Published in:Journal of pharmacy & bioallied science 2011-01, Vol.3 (1), p.39-59
Main Authors: Chiu, Michael H, Prenner, Elmar J
Format: Article
Language:English
Subjects:
antimicrobial peptide
Calorimetry
Chemical properties
Differential scanning calorimetry
drug
drug characterization
drug development
lipid
Lipids
macromolecule
Macromolecules
nanoparticles
pharmaceutical
Proteins
Symposium
Temperature
Thermodynamics
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Summary:Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times, more attention has been applied to lipid-based drug delivery systems and drug interactions with biomimetic membranes. Highly reproducible phase transitions have been used to determine values, such as, the type of binding interaction, purity, stability, and release from a drug delivery mechanism. This review focuses on the use of DSC for biochemical and pharmaceutical applications.
ISSN:0975-7406
0976-4879
0975-7406
0976-4879
DOI:10.4103/0975-7406.76463