Inflammatory Response, a Key Pathophysiological Mechanism of Obesity-Induced Depression

In recent years, with the acceleration of life rhythm and the increase of social competition, the incidence of obesity and depression has been increasing, which has seriously affected the quality of life and health of people. Obesity and depression, two seemingly unrelated physical and psychological...

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Bibliographic Details
Published in:Mediators of inflammation 2020-11, Vol.2020 (2020), p.1-6
Main Authors: Huang, Shu-Ming, Zhang, Bo, Liu, Da-Qian, Shao, Shu-Lin
Format: Article
Language:English
Subjects:
Brain research
Cytokines
Depression, Mental
Endoplasmic reticulum
Genotype & phenotype
Hypotheses
Hypoxia
Inflammation
Mental depression
Metabolism
Neurogenesis
Neurotransmitters
Obesity
Pathogenesis
Psychological aspects
Quality of life
Review
Tumor necrosis factor-TNF
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Summary:In recent years, with the acceleration of life rhythm and the increase of social competition, the incidence of obesity and depression has been increasing, which has seriously affected the quality of life and health of people. Obesity and depression, two seemingly unrelated physical and psychological diseases, in fact, are closely related: obese people are more likely to have depression than nonobese ones. We have reviewed and analyzed the relevant research literature and found that the inflammatory response plays a key role in obesity-induced depression. This article will discuss in detail the inflammatory mechanisms by which obesity induces depression.
ISSN:0962-9351
1466-1861
DOI:10.1155/2020/8893892