Efficacy and safety of bridging therapy and direct mechanical thrombectomy in large vessel occlusions: a meta-analysis

Subgroup analysis showed that functional independence frequency remained unclear between groups regardless of study design (five prospective, 12 retrospectives), and OGT [Supplemental Figures 2–10, http://links.lww.com/CM9/B300].Table 1 Pooled outcomes of bridging therapy and direct mechanical throm...

Full description

Saved in:
Bibliographic Details
Published in:Chinese medical journal 2023-09, Vol.136 (17), p.2119-2121
Main Authors: Li, Zehua, Zhao Linyong, Dilihumaer, Maimaitiming, Wang, Haoran, Sun Leqi, Xiong Weixi
Format: Article
Language:English
Subjects:
Bias
Clinical outcomes
Confounding (Statistics)
Correspondence
Hemorrhage
Meta-analysis
Mortality
Stroke
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Subgroup analysis showed that functional independence frequency remained unclear between groups regardless of study design (five prospective, 12 retrospectives), and OGT [Supplemental Figures 2–10, http://links.lww.com/CM9/B300].Table 1 Pooled outcomes of bridging therapy and direct mechanical thrombectomy in large vessel occlusions by meta-analysis. Subgroup analysis indicated that the 90-day mortality was significantly lower in the BT group regardless of study design or OGT, except for one subgroup (when OGT of intervention group is less than that of control group; OR = 1.35 [95% CI, 0.66–2.03]) [Supplemental Figures 2–10, http://links.lww.com/CM9/B300]. No significant difference was found in the subgroup analysis by study design or OGT [Supplemental Figures 2–10, http://links.lww.com/CM9/B300]. [...]participants who dropped out after some clinical improvements after IVT pretreatment were excluded from all of the studies, which may lead to an overestimation of BT benefit in our analysis.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002272