The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis

Epithelial-mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and dow...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-03, Vol.22 (7), p.3591
Main Authors: Kang, Eunjeong, Seo, Jihye, Yoon, Haelim, Cho, Sayeon
Format: Article
Language:English
Subjects:
Cancer
Embryogenesis
Epithelial-Mesenchymal Transition - genetics
Epithelial-Mesenchymal Transition - physiology
epithelial–mesenchymal transition
Extracellular matrix
Fibroblasts
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Growth factors
Humans
Kinases
Ligands
Mesenchyme
Metastases
Metastasis
Morphology
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasms - genetics
Neoplasms - metabolism
Phosphorylation
Physiology
Post-translation
Protein Processing, Post-Translational - genetics
Protein Processing, Post-Translational - physiology
Proteins
Review
Signal transduction
Snail
Snail Family Transcription Factors - metabolism
transcription factor
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Translation
Twist
Twist Transcription Factors - metabolism
Wound healing
ZEB
Zinc Finger E-box Binding Homeobox 2 - metabolism
Zinc Finger E-box-Binding Homeobox 1 - metabolism
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Description
Summary:Epithelial-mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and down-regulation of specific proteins, both of which are regulated by EMT-inducing transcription factors (EMT-TFs), mainly represented by the families of Snail, Twist, and ZEB proteins. This review highlights the roles of key EMT-TFs and their post-translational regulation in cancer metastasis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22073591