Ácidos siálicos: da compreensão do seu envolvimento em processos biológicos ao desenvolvimento de fármacos contra o agente etiológico da gripe Sialic acids: from the comprehension of their involvement in biological processes to antiinfluenza drug design

Sialic acids are nine-carbon carbohydrates that occur widely in nature and occupy the terminal portions of some glycoproteins and glycolipids of cell membranes. These carbohydrates are closely involved in cell-cell interactions and in processes such as microbial infection, inflammation, etc. Studies...

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Bibliographic Details
Published in:Química nova 2005-03, Vol.28 (2), p.306-316
Main Authors: Ângelo de Fátima, Lúcia Helena Brito Baptistella, Ronaldo Aloise Pilli, Luzia Valentina Modolo
Format: Article
Language:English
Subjects:
flu and antiinfluenza drugs
sialic acid
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Summary:Sialic acids are nine-carbon carbohydrates that occur widely in nature and occupy the terminal portions of some glycoproteins and glycolipids of cell membranes. These carbohydrates are closely involved in cell-cell interactions and in processes such as microbial infection, inflammation, etc. Studies on the participation of sialic acids in biological processes have provided comprehension about their role in the infection by the influenza virus, the causal agent of flu. In this article, we present an overview of the importance of sialic acids in the influenza virus infection and how the knowledge of their involvement in this process has allowed the development of selective and efficient drugs against the virus.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422005000200023