HLA-C04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 Severity

The novel SARS-CoV-2 coronavirus infection has become a global health concern, causing the COVID-19 pandemic. The disease symptoms and outcomes depend on the host immunity, in which the human leukocyte antigen (HLA) molecules play a distinct role. The HLA alleles have an inter-population variability...

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Published in:Frontiers in immunology 2022-02, Vol.13, p.769900
Main Authors: Hovhannisyan, Anahit, Madelian, Vergine, Avagyan, Sevak, Nazaretyan, Mihran, Hyussyan, Armine, Sirunyan, Alina, Arakelyan, Rubina, Manukyan, Zorayr, Yepiskoposyan, Levon, Mayilyan, Karine R, Jordan, Frieda
Format: Article
Language:English
Subjects:
Adult
affinity to SARS-CoV-2
Age Factors
Armenia
Armenian population
COVID-19 - pathology
COVID-19 severity
Female
Gene Frequency - genetics
Heterozygote
Histocompatibility Antigens Class I - genetics
HLA classical genes
HLA-B51 Antigen - genetics
HLA-B51 Antigen - immunology
HLA-C Antigens - genetics
HLA-C Antigens - immunology
HLA-C04:01
HLA-I heterozygosity
Humans
Immunology
Male
Middle Aged
Pandemics
Risk
SARS-CoV-2 - immunology
Severity of Illness Index
Sex Factors
Viral Proteins - immunology
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Summary:The novel SARS-CoV-2 coronavirus infection has become a global health concern, causing the COVID-19 pandemic. The disease symptoms and outcomes depend on the host immunity, in which the human leukocyte antigen (HLA) molecules play a distinct role. The HLA alleles have an inter-population variability, and understanding their link to the COVID-19 in an ethnically distinct population may contribute to personalized medicine. The present study aimed at detecting associations between common HLA alleles and COVID-19 susceptibility and severity in Armenians. In 299 COVID-19 patients (75 asymptomatic, 102 mild/moderate, 122 severe), the association between disease severity and classic HLA-I and II loci was examined. We found that the advanced age, male sex of patients, and sex and age interaction significantly contributed to the severity of the disease. We observed that an age-dependent effect of HLA-B*51:01 carriage [odds ratio (OR)=0.48 (0.28-0.80), P
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.769900