Prospective, randomized study of one, two, or three trabecular bypass stents in open-angle glaucoma subjects on topical hypotensive medication

To assess the safety and efficacy of one, two, or three trabecular microbypass stents in eyes with primary open-angle glaucoma (OAG) not controlled on ocular hypotensive medication. A total of 119 subjects were followed for 18 months postoperatively. Subjects with medicated intraocular pressure (IOP...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2015-01, Vol.9 (Issue 1), p.2313-2320
Main Authors: Katz, L Jay, Erb, Carl, Carceller, Guillamet Amadeu, Fea, Antonio M, Voskanyan, Lilit, Wells, Jeffrey M, Giamporcaro, Jane Ellen
Format: Article
Language:English
Subjects:
Antibiotics
Care and treatment
Cataracts
Confidence intervals
Cornea
Diagnosis
Eye surgery
Eyes
Glaucoma
Implantation
intraocular pressure
IOP reduction
iStent
Lasers
Open-angle glaucoma
Ophthalmology
Original Research
randomized study
Reduction
Stent (Surgery)
Stents
Surgeons
Surgical implants
Systematic review
trabecular bypass
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Summary:To assess the safety and efficacy of one, two, or three trabecular microbypass stents in eyes with primary open-angle glaucoma (OAG) not controlled on ocular hypotensive medication. A total of 119 subjects were followed for 18 months postoperatively. Subjects with medicated intraocular pressure (IOP) 18-30 mmHg and postmedication-washout baseline IOP 22-38 mmHg were randomized to implantation of one, two, or three stents. Ocular hypotensive medication was to be used if postoperative IOP exceeded 18 mmHg. A total of 38 subjects were implanted with one stent, 41 subjects with two stents, and 40 subjects with three stents. Both month 12 IOP reduction ≥20% without ocular hypotensive medication vs baseline unmedicated IOP and month 12 unmedicated IOP ≤18 mmHg were achieved by 89.2%, 90.2%, and 92.1% of one-, two-, and three-stent eyes, respectively. Furthermore, 64.9%, 85.4%, and 92.1% of the three respective groups achieved unmedicated IOP ≤15 mmHg. Over the 18-month follow-up period, medication was required in seven one-stent subjects, four two-stent subjects, and three three-stent subjects. At 18 months, mean unmedicated IOP was 15.9±0.9 mmHg in one-stent subjects, 14.1±1.0 mmHg in two-stent subjects, and 12.2±1.1 mmHg in three-stent subjects. Month 18 IOP reduction was significantly greater (P
ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S96695