Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012-2018

The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012-2018 (vaccine era), using multivariable logistic regression by manu...

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Bibliographic Details
Published in:Emerging infectious diseases 2022-01, Vol.28 (1), p.166-179
Main Authors: Müller, Annelies, Kleynhans, Jackie, de Gouveia, Linda, Meiring, Susan, Cohen, Cheryl, Hathaway, Lucy Jane, von Gottberg, Anne
Format: Article
Language:English
Subjects:
Age groups
Antigens
bacteria
Causes of
Disease prevention
Fatalities
Health surveillance
Humans
Identification and classification
Immunization
Infant
Laboratories
Meningitis
meningitis/encephalitis
Original Research
Patient outcomes
Patients
Pneumococcal infections
Pneumococcal Infections - epidemiology
Pneumococcal Vaccines
Serogroup
serotype
Serotypes Associated with Death, South Africa, 2012–2018
South Africa - epidemiology
Statistical analysis
streptococci
Streptococcus
Streptococcus infections
Streptococcus pneumoniae
Vaccines
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Summary:The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012-2018 (vaccine era), using multivariable logistic regression by manual backward elimination. The most common serotypes causing IPD were 8 and 19A. In patients 15 years of age, serotype 15B/C was associated with increased CFR. Among meningitis patients of all ages, serotype 1 was associated with increased CFR. PCV13 serotypes 1, 3, 6A, 19A, and 19F should be monitored, and serotypes 8, 12F, 15A, and 15B/C should be considered for inclusion in vaccines to reduce deaths caused by S. pneumoniae.
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2801.210956