Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing

Approximately half of bone fractures that do not heal properly (non-union) can be accounted to insufficient angiogenesis. The processes of angiogenesis and osteogenesis are spatiotemporally regulated in the complex process of fracture healing that requires a substantial amount of energy. It is thoug...

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Bibliographic Details
Published in:Bone Reports 2024-06, Vol.21, p.101757-101757, Article 101757
Main Authors: van Brakel, Fleur, Zhao, Yudong, van der Eerden, Bram C.J.
Format: Article
Language:English
Subjects:
Angiogenesis
Bone regeneration
Energy metabolism
Fracture healing
Metabolic coupling
Osteogenesis
Review
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Summary:Approximately half of bone fractures that do not heal properly (non-union) can be accounted to insufficient angiogenesis. The processes of angiogenesis and osteogenesis are spatiotemporally regulated in the complex process of fracture healing that requires a substantial amount of energy. It is thought that a metabolic coupling between angiogenesis and osteogenesis is essential for successful healing. However, how this coupling is achieved remains to be largely elucidated. Here, we will discuss the most recent evidence from literature pointing towards a metabolic coupling between angiogenesis and osteogenesis. We will describe the metabolic profiles of the cell types involved during fracture healing as well as secreted products in the bone microenvironment (such as lactate and nitric oxide) as possible key players in this metabolic crosstalk.
ISSN:2352-1872
2352-1872
DOI:10.1016/j.bonr.2024.101757