Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China

• Published in: BMC pediatrics 2022-12, Vol.22 (1), p.697-697, Article 697
• Main Authors: Tan, Shan, Li, Shizhou, Dong, Jianxiang, Dai, Hongmei, Yang, Minghua, Sun, Fang, Yang, Yang, Jiang, Jie, Zhu, Shan, Zhao, Mingyi, Chen, Zhiheng
• Format: Article
• Language: English
• Subjects: Age; Anemia; Body mass index; Chi-square test; Child, Preschool; Children; China - epidemiology; Colds; HBV vaccine; Hepatitis; Hepatitis B; Hepatitis B - epidemiology; Hepatitis B - prevention & control; Hepatitis B Antibodies; Hepatitis B surface antibody; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Infant; Infections; Logistics; Male; Normal distribution; Nutrition; Pediatrics; Regression analysis; Retrospective Studies; Vaccines; Vitamin D; Zinc
• ISSN: 1471-2431; 1471-2431
• DOI: 10.1186/s12887-022-03718-z

Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instructions for HBV prevention clinically. The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P