Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China

Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instruction...

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Published in:BMC pediatrics 2022-12, Vol.22 (1), p.697-697, Article 697
Main Authors: Tan, Shan, Li, Shizhou, Dong, Jianxiang, Dai, Hongmei, Yang, Minghua, Sun, Fang, Yang, Yang, Jiang, Jie, Zhu, Shan, Zhao, Mingyi, Chen, Zhiheng
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description Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instructions for HBV prevention clinically. The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P 
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This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instructions for HBV prevention clinically. The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P &lt; 0.10) in chi-square test or T test were further assessed with collinearity and chosen for univariate and multivariate logistic regression analysis by the stepwise backward maximum likelihood method (α  = 0.05, α  = 0.10). A total of 5838 samples (3362 males, 57.6%) were enrolled. In total, the incidence of negative anti-HBs increased with age[OR = 1.037(1.022-1.051)]. Multivariate logistic regression analysis illustrated that anemia[OR = 0.392(0.185-0.835)], age[OR = 2.542(1.961-3.295)] and Vit D[OR = 0.977(0.969-0.984)] in 0.5-2.99 years subgroup, Zinc deficiency[OR = 0.713(0.551-0.923] and age[OR = 1.151(1.028-1.289)] in 3-5.99 years subgroup, Vit D[OR = 0.983(0.971-0.995)] in 12-18 years subgroup had significant association with anti-HBs. 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The Author(s).</rights><rights>COPYRIGHT 2022 BioMed Central Ltd.</rights><rights>2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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subjects Age
Anemia
Body mass index
Chi-square test
Child, Preschool
Children
China - epidemiology
Colds
HBV vaccine
Hepatitis
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - prevention & control
Hepatitis B Antibodies
Hepatitis B surface antibody
Hepatitis B Surface Antigens
Hepatitis B Vaccines
Hepatitis B virus
Humans
Infant
Infections
Logistics
Male
Normal distribution
Nutrition
Pediatrics
Regression analysis
Retrospective Studies
Vaccines
Vitamin D
Zinc
title Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China
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