Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China
Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instruction...
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Published in: | BMC pediatrics 2022-12, Vol.22 (1), p.697-697, Article 697 |
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description | Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instructions for HBV prevention clinically.
The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P |
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The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P < 0.10) in chi-square test or T test were further assessed with collinearity and chosen for univariate and multivariate logistic regression analysis by the stepwise backward maximum likelihood method (α
= 0.05, α
= 0.10).
A total of 5838 samples (3362 males, 57.6%) were enrolled. In total, the incidence of negative anti-HBs increased with age[OR = 1.037(1.022-1.051)]. Multivariate logistic regression analysis illustrated that anemia[OR = 0.392(0.185-0.835)], age[OR = 2.542(1.961-3.295)] and Vit D[OR = 0.977(0.969-0.984)] in 0.5-2.99 years subgroup, Zinc deficiency[OR = 0.713(0.551-0.923] and age[OR = 1.151(1.028-1.289)] in 3-5.99 years subgroup, Vit D[OR = 0.983(0.971-0.995)] in 12-18 years subgroup had significant association with anti-HBs.
This retrospective study illustrated that age, anemia status, zinc deficiency and vitamin D were associated with anti-HBs expression in specific age groups of children, which could serve as a reference for the prevention of HBV.</description><identifier>ISSN: 1471-2431</identifier><identifier>EISSN: 1471-2431</identifier><identifier>DOI: 10.1186/s12887-022-03718-z</identifier><identifier>PMID: 36471266</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Age ; Anemia ; Body mass index ; Chi-square test ; Child, Preschool ; Children ; China - epidemiology ; Colds ; HBV vaccine ; Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - prevention & control ; Hepatitis B Antibodies ; Hepatitis B surface antibody ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Hepatitis B virus ; Humans ; Infant ; Infections ; Logistics ; Male ; Normal distribution ; Nutrition ; Pediatrics ; Regression analysis ; Retrospective Studies ; Vaccines ; Vitamin D ; Zinc</subject><ispartof>BMC pediatrics, 2022-12, Vol.22 (1), p.697-697, Article 697</ispartof><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 BioMed Central Ltd.</rights><rights>2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c545t-619f5fe986654f3768e69be52a211c05e336e5d699c6ee45ec84982447bfb6cb3</cites><orcidid>0000-0003-1243-8010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724425/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2755651166?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36471266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Shan</creatorcontrib><creatorcontrib>Li, Shizhou</creatorcontrib><creatorcontrib>Dong, Jianxiang</creatorcontrib><creatorcontrib>Dai, Hongmei</creatorcontrib><creatorcontrib>Yang, Minghua</creatorcontrib><creatorcontrib>Sun, Fang</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Zhu, Shan</creatorcontrib><creatorcontrib>Zhao, Mingyi</creatorcontrib><creatorcontrib>Chen, Zhiheng</creatorcontrib><title>Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China</title><title>BMC pediatrics</title><addtitle>BMC Pediatr</addtitle><description>Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instructions for HBV prevention clinically.
The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P < 0.10) in chi-square test or T test were further assessed with collinearity and chosen for univariate and multivariate logistic regression analysis by the stepwise backward maximum likelihood method (α
= 0.05, α
= 0.10).
A total of 5838 samples (3362 males, 57.6%) were enrolled. In total, the incidence of negative anti-HBs increased with age[OR = 1.037(1.022-1.051)]. Multivariate logistic regression analysis illustrated that anemia[OR = 0.392(0.185-0.835)], age[OR = 2.542(1.961-3.295)] and Vit D[OR = 0.977(0.969-0.984)] in 0.5-2.99 years subgroup, Zinc deficiency[OR = 0.713(0.551-0.923] and age[OR = 1.151(1.028-1.289)] in 3-5.99 years subgroup, Vit D[OR = 0.983(0.971-0.995)] in 12-18 years subgroup had significant association with anti-HBs.
This retrospective study illustrated that age, anemia status, zinc deficiency and vitamin D were associated with anti-HBs expression in specific age groups of children, which could serve as a reference for the prevention of HBV.</description><subject>Age</subject><subject>Anemia</subject><subject>Body mass index</subject><subject>Chi-square test</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>China - epidemiology</subject><subject>Colds</subject><subject>HBV vaccine</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B Antibodies</subject><subject>Hepatitis B surface antibody</subject><subject>Hepatitis B Surface Antigens</subject><subject>Hepatitis B Vaccines</subject><subject>Hepatitis B virus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Logistics</subject><subject>Male</subject><subject>Normal distribution</subject><subject>Nutrition</subject><subject>Pediatrics</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Vaccines</subject><subject>Vitamin D</subject><subject>Zinc</subject><issn>1471-2431</issn><issn>1471-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1vEzEQhlcIREvhD3BAKyEhDmxZe_15QSpRIZUqwQHOZtY7mzja2MHejaC_HqcJVYKQDx7NPPOOPXqL4iWpLwlR4n0iVClZ1ZRWdSOJqu4eFeeESVJR1pDHR_FZ8SylVV0TqZh4Wpw1IleoEOfFj-stDBOMLvgy9GUPdgwxlZBSsA5G7MpxiSX-2kRM6QCBH101_5hK50u7dEMX0e_i-eTBl19j2Dpv8V05WzoPz4snPQwJXxzui-L7p-tvs3l1--XzzezqtrKc8bESRPe8R62E4KxvpFAodIucAiXE1hybRiDvhNZWIDKOVjGtKGOy7Vth2-aiuNnrdgFWZhPdGuJvE8CZ-0SICwNxdHZA01ltgWihed5Dw7kmbR4IjNWtVIRB1vqw19pM7Ro7i36MMJyInla8W5pF2Bot84sozwJvDwIx_JwwjWbtksVhAI9hSoZKJqmUnIiMvv4HXYUp-ryqTHEuOCHiiFpA_oDzfchz7U7UXEmqa05rpTJ1-R8qnw7XzgaPvcv5k4Y3Rw1LhGFcpjBMOzukU5DuQRtDShH7h2WQ2uzMaPZmNNmM5t6M5i43vTpe40PLX_c1fwDNRddl</recordid><startdate>20221206</startdate><enddate>20221206</enddate><creator>Tan, Shan</creator><creator>Li, Shizhou</creator><creator>Dong, Jianxiang</creator><creator>Dai, Hongmei</creator><creator>Yang, Minghua</creator><creator>Sun, Fang</creator><creator>Yang, Yang</creator><creator>Jiang, Jie</creator><creator>Zhu, Shan</creator><creator>Zhao, Mingyi</creator><creator>Chen, Zhiheng</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1243-8010</orcidid></search><sort><creationdate>20221206</creationdate><title>Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China</title><author>Tan, Shan ; Li, Shizhou ; Dong, Jianxiang ; Dai, Hongmei ; Yang, Minghua ; Sun, Fang ; Yang, Yang ; Jiang, Jie ; Zhu, Shan ; Zhao, Mingyi ; Chen, Zhiheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-619f5fe986654f3768e69be52a211c05e336e5d699c6ee45ec84982447bfb6cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Anemia</topic><topic>Body mass index</topic><topic>Chi-square test</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>China - epidemiology</topic><topic>Colds</topic><topic>HBV vaccine</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B Antibodies</topic><topic>Hepatitis B surface antibody</topic><topic>Hepatitis B Surface Antigens</topic><topic>Hepatitis B Vaccines</topic><topic>Hepatitis B virus</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Logistics</topic><topic>Male</topic><topic>Normal distribution</topic><topic>Nutrition</topic><topic>Pediatrics</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Vaccines</topic><topic>Vitamin D</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Shan</creatorcontrib><creatorcontrib>Li, Shizhou</creatorcontrib><creatorcontrib>Dong, Jianxiang</creatorcontrib><creatorcontrib>Dai, Hongmei</creatorcontrib><creatorcontrib>Yang, Minghua</creatorcontrib><creatorcontrib>Sun, Fang</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Zhu, Shan</creatorcontrib><creatorcontrib>Zhao, Mingyi</creatorcontrib><creatorcontrib>Chen, Zhiheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>BMC pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Shan</au><au>Li, Shizhou</au><au>Dong, Jianxiang</au><au>Dai, Hongmei</au><au>Yang, Minghua</au><au>Sun, Fang</au><au>Yang, Yang</au><au>Jiang, Jie</au><au>Zhu, Shan</au><au>Zhao, Mingyi</au><au>Chen, Zhiheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China</atitle><jtitle>BMC pediatrics</jtitle><addtitle>BMC Pediatr</addtitle><date>2022-12-06</date><risdate>2022</risdate><volume>22</volume><issue>1</issue><spage>697</spage><epage>697</epage><pages>697-697</pages><artnum>697</artnum><issn>1471-2431</issn><eissn>1471-2431</eissn><abstract>Vaccine is the most essential avenue to prevent hepatitis B virus (HBV) infection in infants and preschool children in China, with the largest populations carrying HBV in the world. This study aimed to evaluate the factors associating the response level of anti-HBs in children, providing instructions for HBV prevention clinically.
The children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. Grouping by age and anti-HBs expression, we used chi-square test and T test to compare qualitative and quantitative data between positive group and negative group in each age subgroup. The meaningful variables (P < 0.10) in chi-square test or T test were further assessed with collinearity and chosen for univariate and multivariate logistic regression analysis by the stepwise backward maximum likelihood method (α
= 0.05, α
= 0.10).
A total of 5838 samples (3362 males, 57.6%) were enrolled. In total, the incidence of negative anti-HBs increased with age[OR = 1.037(1.022-1.051)]. Multivariate logistic regression analysis illustrated that anemia[OR = 0.392(0.185-0.835)], age[OR = 2.542(1.961-3.295)] and Vit D[OR = 0.977(0.969-0.984)] in 0.5-2.99 years subgroup, Zinc deficiency[OR = 0.713(0.551-0.923] and age[OR = 1.151(1.028-1.289)] in 3-5.99 years subgroup, Vit D[OR = 0.983(0.971-0.995)] in 12-18 years subgroup had significant association with anti-HBs.
This retrospective study illustrated that age, anemia status, zinc deficiency and vitamin D were associated with anti-HBs expression in specific age groups of children, which could serve as a reference for the prevention of HBV.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>36471266</pmid><doi>10.1186/s12887-022-03718-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1243-8010</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Anemia Body mass index Chi-square test Child, Preschool Children China - epidemiology Colds HBV vaccine Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - prevention & control Hepatitis B Antibodies Hepatitis B surface antibody Hepatitis B Surface Antigens Hepatitis B Vaccines Hepatitis B virus Humans Infant Infections Logistics Male Normal distribution Nutrition Pediatrics Regression analysis Retrospective Studies Vaccines Vitamin D Zinc |
title | Evaluation of factors associated the expression of anti-HBs in children in Hunan Province, China |
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