Elucidating the host–pathogen interaction between human colorectal cells and invading Enterovirus 71 using transcriptomics profiling

[Display omitted] •Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD).•Types I, II and III interferon may be a key antiviral response against EV71.•We examine the transcriptomic changes in human colorectal cells during EV71 infection.•The intestinal e...

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Bibliographic Details
Published in:FEBS open bio 2014-01, Vol.4 (1), p.426-431
Main Authors: Lui, Yan Long Edmund, Tan, Tuan Lin, Timms, Peter, Hafner, Louise Marie, Tan, Kian Hwa, Tan, Eng Lee
Format: Article
Language:English
Subjects:
Colorectal cells
DNA microarrays
Enterovirus
Enterovirus 71
Epidemics
FDA approval
Gene expression
Genomes
Hand, Foot and Mouth Disease
Immune response
Immune system
Infections
Laboratories
Medical prognosis
Microarray
mRNA profiling
Nervous system
Pathogenesis
Pathogens
Polymerase chain reaction
Transcriptomics
Viruses
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Summary:[Display omitted] •Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD).•Types I, II and III interferon may be a key antiviral response against EV71.•We examine the transcriptomic changes in human colorectal cells during EV71 infection.•The intestinal epithelial immune system plays a key role in the progression of HFMD. Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host–pathogen interaction between human colorectal cells and EV71.
ISSN:2211-5463
2211-5463
DOI:10.1016/j.fob.2014.04.005