Emerging Trends in Bilosomes as Therapeutic Drug Delivery Systems

In recent years, there has been a notable surge in the utilization of stabilized bile acid liposomes, chemical conjugates, complexes, mixed micelles, and other drug delivery systems derived from bile acids, often referred to as bilosomes. The molecular structure and interactions of these amphiphilic...

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Published in:Pharmaceutics 2024-05, Vol.16 (6), p.697
Main Authors: Kaurav, Hemlata, Tripathi, Meenakshi, Kaur, Simran Deep, Bansal, Amit, Kapoor, Deepak N, Sheth, Sandeep
Format: Article
Language:English
Subjects:
Antigens
Bile
bile salts
bilosomes
Bioavailability
Biocompatibility
Cholesterol
drug delivery
Drug delivery systems
Drugs
Efficiency
Lipids
Peptides
Permeability
Phase transitions
Proteins
Review
Surfactants
topical delivery
ultra-deformable vesicles
Vaccines
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Summary:In recent years, there has been a notable surge in the utilization of stabilized bile acid liposomes, chemical conjugates, complexes, mixed micelles, and other drug delivery systems derived from bile acids, often referred to as bilosomes. The molecular structure and interactions of these amphiphilic compounds provide a distinctive and captivating subject for investigation. The enhanced stability of new generation bilosomes inside the gastrointestinal system results in the prevention of drug degradation and an improvement in mucosal penetration. These characteristics render bilosomes to be a prospective nanocarrier for pharmaceutical administration, prompting researchers to investigate their potential in other domains. This review paper discusses bilosomes that have emerged as a viable modality in the realm of drug delivery and have significant promise for use across several domains. Moreover, this underscores the need for additional investigation and advancement in order to comprehensively comprehend the prospective uses of bilosomes and their effectiveness in the field of pharmaceutical administration. This review study explores the current scholarly attention on bilosomes as prospective carriers for drug delivery. Therapeutic areas where bilosomes have shown outstanding performance in terms of drug delivery are outlined in the graphical abstract.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16060697