NF-κB Pathway and Its Inhibitors: A Promising Frontier in the Management of Alzheimer’s Disease

The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer’s disease (AD). The involvement of the NF-κB pathway in immune system responses, inflammation, oxidative stress, and neuronal survi...

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Bibliographic Details
Published in:Biomedicines 2023-09, Vol.11 (9), p.2587
Main Authors: Sivamaruthi, Bhagavathi Sundaram, Raghani, Neha, Chorawala, Mehul, Bhattacharya, Sankha, Prajapati, Bhupendra G, Elossaily, Gehan M, Chaiyasut, Chaiyavat
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer's disease
amyloid beta plaques
Avanafil
Cytokines
Dementia
Development and progression
Gene expression
Hypotheses
Immune response
Inflammation
Influence
Kinases
Melatonin
MicroRNAs
Nervous system
Neurodegeneration
Neurodegenerative diseases
neuroinflammation
Neurons
NF-κB
NF-κB protein
Oxidative stress
Pathogenesis
Pathogens
Phosphorylation
Physiological aspects
phytochemicals
Proteins
Review
Target marketing
Therapeutic targets
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Summary:The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer’s disease (AD). The involvement of the NF-κB pathway in immune system responses, inflammation, oxidative stress, and neuronal survival highlights its significance in AD progression. We discuss the advantages of NF-κB pathway inhibition, including the potential to mitigate neuroinflammation, modulate amyloid beta (Aβ) production, and promote neuronal survival. However, we also acknowledge the limitations and challenges associated with this approach. Balancing the fine line between dampening inflammation and preserving physiological immune responses is critical to avoid unintended consequences. This review combines current knowledge on the NF-κB pathway’s intricate involvement in AD pathogenesis, emphasizing its potential as a therapeutic target. By evaluating both advantages and limitations, we provide a holistic view of the feasibility and challenges of NF-κB pathway modulation in AD treatment. As the quest for effective AD therapies continues, an in-depth understanding of the NF-κB pathway’s multifaceted roles will guide the development of targeted interventions with the potential to improve AD management.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11092587