Successful therapeutic approach in a patient with elephantiasic pretibial myxedema

Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5–4% of patients with Graves’ disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial reg...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2020-07, Vol.95 (4), p.469-472
Main Authors: Ferreira, Marina, Zacaron, Luciana Helena, Valle, Annair Freitas do, Gamonal, Aloisio Carlos Couri
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones
Case Report
DERMATOLOGY
Evaluation of results of therapeutic interventions
Female
Graves Disease
Humans
Leg Dermatoses
Middle Aged
Myxedema
Steroids
Therapeutics
Triamcinolone
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Summary:Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5–4% of patients with Graves’ disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial region. Clinically, it presents as a localized, circumscribed, and non-depressible infiltrate in plaques. Several treatment modalities have been proposed, and their results vary, with worse response observed in severe cases. This report presents the case of a patient with elephantiasic pretibial myxedema who was subjected to intralesional corticosteroid applications, resulting in an excellent and encouraging therapeutic response that was maintained.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1016/j.abd.2019.02.007