Multi-Level Optimization and Strategies in Microbial Biotransformation of Nature Products

Continuously growing demand for natural products with pharmacological activities has promoted the development of microbial transformation techniques, thereby facilitating the efficient production of natural products and the mining of new active compounds. Furthermore, due to the shortcomings and def...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-03, Vol.28 (6), p.2619
Main Authors: Qin, Dan, Dong, Jinyan
Format: Article
Language:English
Subjects:
Analytical methods
Bacteria
Biological Products - metabolism
Biotransformation
Chemical synthesis
Efficiency
Enzymes
Fermentation
Fungi
Metabolism
Metabolites
microbial transformation
Microorganisms
multi-level optimization
Natural products
Optimization
Pharmaceutical industry
Review
Synthetic biology
Technology
Transformations
Vincristine
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Summary:Continuously growing demand for natural products with pharmacological activities has promoted the development of microbial transformation techniques, thereby facilitating the efficient production of natural products and the mining of new active compounds. Furthermore, due to the shortcomings and defects of microbial transformation, it is an important scientific issue of social and economic value to improve and optimize microbial transformation technology in increasing the yield and activity of transformed products. In this review, the aspects regarding the optimization of fermentation and the cross-disciplinary strategy, leading to the microbial transformation of increased levels of the high-efficiency process from natural products of a plant or microbial origin, were discussed. Additionally, due to the increasing craving for targeted and efficient methods for detecting transformed metabolites, analytical methods based on multiomics were also discussed. Such strategies can be well exploited and applied to the production of more efficient and more natural products from microbial resources.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28062619