Factors that affect the development of acute hemorrhagic rectal ulcer syndrome and rebleeding

• Published in: DEN open 2023-04, Vol.3 (1), p.e184-n/a
• Main Authors: Uehara, Natsumi, Inoue, Kazuaki, Kuroki, Yuichiro, Miyao, Naoki, Iwahashi, Kenta, Suzuki, Reika, Endo, Toshiyuki, Asonuma, Kunio, Yoshida, Erika, Koshibu, Naoko, Tabuchi, Akihiro, Tohata, Misako, Hanamura, Shotaro, Gomi, Kuniyo, Yamamoto, Yorimasa, Nagahama, Masatsugu
• Format: Article
• Language: English
• Subjects: Blood vessels; Cancer; Cerebrovascular disease; Diabetes; Endoscopy; Hemodialysis; hemorrhage; hemostasis; Hospitals; Medical prognosis; Morphology; Mortality; Original; Patients; Plasma; rectum; Steroids; ulcer; Ulcers
• ISSN: 2692-4609; 2692-4609
• DOI: 10.1002/deo2.184

Objectives Acute hemorrhagic rectal ulcer syndrome (AHRUS) causes massive bleeding and often recurrent rebleeding from rectal ulcers that form immediately above the dentate line. This study aimed to determine the clinical background and risk factors contributing to rebleeding in patients with AHRUS and the most appropriate method of hemostasis treatment. Methods This retrospective study included 93 patients diagnosed with AHRUS at Showa University Fujigaoka Hospital, Japan, between April 2009 and November 2018. Information on clinical background factors, endoscopic findings, and hemostasis was obtained from medical records. The relationship with episodes of rebleeding was analyzed by multivariate logistic regression analysis. Results The median age was 79 years, and 84 patients (90%) had a performance status of grade 2 or higher. The patients had multiple background factors, with a median number of 5 per patient. The background factors could be classified into two major factors: those related to arteriosclerosis and those related to delayed wound healing. In the multivariate analysis, significantly more rebleeding occurred in patients with active bleeding during the initial endoscopy (odds ratio 4.88, 95% confidence interval 1.80–14.46, p = 0.003); significantly less rebleeding occurred in patients for whom hemostasis was first performed by clipping (odds ratio 0.30, 95% confidence interval 0.09–0.88, p = 0.035). Conclusions In bedridden older individuals with poor general health, multiple combinations of arteriosclerosis‐related factors and protracted wound healing factors can induce AHRUS. We strongly recommend performing hemostasis via the clipping method on suspected bleeding points, including active bleeding sites, in AHRUS.