Evaluation of Changes in Metabolites of Saliva in Canine Obesity Using a Targeted Metabolomic Approach

Obesity is a common problem in pet dogs, affecting half of the general population in some countries. Excess body weight causes several disorders and has a negative impact on dogs’ quality of life. The use of metabolomics allows the identification of metabolite traces from the metabolic pathways invo...

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Bibliographic Details
Published in:Animals (Basel) 2021-08, Vol.11 (9), p.2501
Main Authors: Muñoz-Prieto, Alberto, Rubić, Ivana, Horvatić, Anita, Rafaj, Renata Barić, Cerón, José Joaquín, Tvarijonaviciute, Asta, Mrljak, Vladimir
Format: Article
Language:English
Subjects:
Biomarkers
Body weight
Chromatography
Discriminant analysis
Disease
Dogs
Epidemics
Evaluation
Glycerides
Insulin
Insulin resistance
Life sciences
Mass spectrometry
Metabolic disorders
Metabolic pathways
Metabolites
Metabolomics
Multivariate analysis
Obesity
Oils & fats
Pets
Proteins
Quality of life
Saliva
Scientific imaging
Software
Sphingolipids
Statistical analysis
targeted metabolomics
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Summary:Obesity is a common problem in pet dogs, affecting half of the general population in some countries. Excess body weight causes several disorders and has a negative impact on dogs’ quality of life. The use of metabolomics allows the identification of metabolite traces from the metabolic pathways involved in pathological processes. This study aimed to evaluate salivary metabolite variations in dogs with obesity. The salivary samples of 19 dogs were analyzed using a targeted metabolomic approach, through which 234 metabolites were quantified. Of these, multivariate analysis identified 27 different metabolites altered in dogs with obesity compared with control dogs. These metabolites were mainly classified as amino acids, glycerides, sphingolipids, glycerophospholipids, and acylcarnitines. Some of the changes in these metabolites reflect the insulin resistance status related to obesity in dogs. Overall, it can be concluded that the salivary metabolome of obese dogs reflects the metabolic changes occurring in obesity and could be a source of potential biomarkers for this complex condition.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani11092501